Long-term results of nephron sparing surgery for localized renal cell carcinoma: 10-year followup
Long-term results of nephron sparing surgery for localized renal cell carcinoma: 10-year followup
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DOI：
10.1016/s0022-5347(05)67896-2
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发表时间：
2000-02-01
影响因子：
6.6
通讯作者：
Novick, AC
中科院分区：
文献类型：
--
作者：
Fergany, AF;Hafez, KS;Novick, AC
目的：肾部分切除术是治疗肾细胞癌的有效方法，但需考虑保留肾功能。材料与方法：对1988年12月以前的107例局限性散发性肾细胞癌患者行肾部分切除术。73名患者(68%)肿瘤有症状，96名患者(90%)需要手术指征。其中42例(39%)术前有肾功能不全。结果：随访结束时32例(30%)患者无复发迹象，28例(26%)死于转移性肾细胞癌，46例(42%)死于其他原因。5年和10年的肿瘤特异性生存率分别为88.2%和73%，肿瘤分期、症状、肿瘤偏侧性和肿瘤大小对生存率有显著影响。52例(49%)患者长期肾功能稳定。结论：肾部分切除术是治疗局限性肾细胞癌的有效方法，可在保留肾功能的情况下提供长期的肿瘤控制。
Purpose: Partial nephrectomy is effective for renal cell carcinoma when preservation of renal function is a concern. We present the 10-year followup of patients treated with nephron sparing surgery at our institution.Materials and Methods: Partial nephrectomy was performed in 107 patients with localized sporadic renal cell carcinoma before December 1988. Tumors were symptomatic in 73 patients (68%) and indications for surgery were imperative in 96 (90%). Of the patients 42 (39%) had renal insufficiency preoperatively. All patients were followed a minimum of 10 years or until death.Results: At the end of the followup interval 32 patients (30%) had no evidence of recurrence, 28 (26%) died of metastatic renal cell carcinoma and 46 (42%) died of unrelated causes. Cancer specific survival was 88.2% at 5 and 73% at 10 years, and was significantly affected by tumor stage, symptoms, tumor laterality and tumor size. Long-term renal function was stable in 52 patients (49%).Conclusions: Partial nephrectomy is effective for localized renal cell carcinoma, providing long-term tumor control with preservation of renal function.