Peripheral blood Ia-positive T cells. Increases in certain diseases and after immunization.
Peripheral blood Ia-positive T cells. Increases in certain diseases and after immunization.
复制标题
外周血 Ia 阳性 T 细胞。某些疾病和免疫后增加。
DOI：
10.1084/jem.151.1.91
复制
发表时间：
1980-01-01
影响因子：
15.3
通讯作者：
Kunkel, H G
中科院分区：
文献类型：
--
作者：
Yu, D T;Winchester, R J;Fu, S M;Gibofsky, A;Ko, H S;Kunkel, H G
Ia抗原通常主要在B淋巴细胞上表达，在一小部分正常外周血T细胞上发现（荧光检测平均为2.6%，玫瑰花结检测平均为10.8%）。在类风湿关节炎患者中，两种方法均观察到高达40%的水平升高。在系统性红斑狼疮和各种感染的患者中也发现了增加。特异性异源抗血清、杂交瘤试剂和DR特异性异源抗血清均明显增加。正常水平存在于多发性硬化症和各种代谢和其他疾病。在破伤风类毒素或PPD免疫后，正常个体中出现类似阳性T细胞的增加。所有这些病例中主要涉及的细胞是小淋巴细胞，荧光试剂对其染色相对较弱，很容易与t细胞母细胞区分开来。它们被发现在分离的T γ部分中富集，但在其他T细胞中也被发现。积累的证据表明，这些细胞代表了正常个体中发现的一种或多种T细胞亚群的扩增，并且它们在外周血中的水平可以作为免疫刺激的指标。
The Ia antigens, usually expressed primarily on B lymphocytes, are found on a small percentage of normal peripheral blood T cells (average 2.6% by fluorescence and 10.8% by rosette assay). Elevated levels up to 40% by both assays were observed in a high proportion of patients with rheumatoid arthritis. Increases also were found in patients with systemic lupus erythematosus and various types of infections. The increases were evident with a specific heteroantiserum, a hybridoma reagent, and DR specific alloantisera. Normal levels were present in multiple sclerosis and an assortment of metabolic and other disorders. A rise in similarly positive T cells occurred in normal individuals after immunization with tetanus toxoid or PPD. The cells primarily involved in all of these instances were small lymphocytes, which stained relatively weakly with the fluorescent reagents and were readily distinguishable from T-cell blasts. They were found to be enriched in isolated T gamma fractions but were also found in other T cells. The accumulated evidence indicated that these cells represent an expansion of one or more subsets of T cells found in normal individuals, and that their level in the peripheral blood may serve as an index of immunological stimulation.