Disintegrative disorder or "late onset" autism.
Disintegrative disorder or "late onset" autism.
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崩解性障碍或“迟发性”自闭症。
DOI：
10.1111/j.1469-7610.1989.tb00784.x
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Cohen,DJ
中科院分区：
文献类型：
--
作者：
Volkmar,FR;Cohen,DJ
在165名符合自闭症行为标准的更大样本中，发现了10例解体障碍病例。研究人员将这些病例与两岁前发现障碍的自闭症患者和两岁后发现障碍的自闭症患者进行了比较。与之前的报告一致，分裂障碍儿童在开始严重的发育退化之前有一段正常的发育期，但他们最多只能进行有限的恢复。回归时的临床特征和各种结果衡量标准都支持诊断概念的有效性，特别是当将此类病例与“晚发型”自闭症患者进行比较时。
Ten cases of disintegrative disorder were identified within a larger sample of 165 individuals who met behavioral criteria for autism. These cases were compared to autistic individuals whose disorder had been recognized by age 2 and to those whose disorder had been recognized after age 2. Consistent with previous reports, children with disintegrative disorder had a period of normal development preceding the onset of a profound developmental regression from which they made, at best, only a limited recovery. Both clinical features at the time of regression and various outcome measures support the validity of the diagnostic concept, particularly when such cases are compared to “late onset” autistic ones.