Role of myeloid cells in the regulation of group 2 innate lymphoid cell-mediated allergic inflammation
Role of myeloid cells in the regulation of group 2 innate lymphoid cell-mediated allergic inflammation
复制标题
骨髓细胞在调节第 2 组先天淋巴细胞介导的过敏性炎症中的作用
作者：
Lei Aihua;He Yumei;Yang Qiong;Li Xiaofang;Li Ranhui
第2组先天淋巴样细胞（ILC2）是先天免疫系统的重要组成部分，其在屏障表面（例如肺和皮肤）执行重要的效应子功能。与辅助性T细胞2型一样，ILC2能够释放大量的2型细胞因子，这些细胞因子在诱导过敏性炎症和消除蠕虫感染中至关重要。在过去的几年里，我们更好地理解了ILC2与免疫系统其他细胞之间通过可溶性因子或细胞-细胞接触方式的相互作用。髓样细胞，包括单核白细胞和多形核白细胞，是组织损伤和感染的良好传感器，并且可以影响过敏性炎症过程中的ILC2应答。在这篇综述中，我们总结了最近的见解，髓样细胞亚群如何调节ILC2激活，重点是可溶性因子在过敏性炎症的背景下。
Group 2 innate lymphoid cells (ILC2s) are an important component of the innate immune system that execute important effector functions at barrier surfaces, such as lung and skin. Like T helper type 2 cells, ILC2s are able to release high amounts of type 2 cytokines that are essential in inducing allergic inflammation and eliminating helminth infections. The past few years have contributed to our better understanding of the interactions between ILC2s and other cells of the immune system via soluble factors or in a cell–cell contact manner. Myeloid cells, including mononuclear leukocytes and polymorphonuclear leukocytes, are excellent sensors of tissue damage and infection and can influence ILC2 responses in the process of allergic inflammation. In this review, we summarize recent insights on how myeloid cell subsets regulate ILC2 activation with focus on soluble factors in the context of allergic inflammation.