Lung clearance index and exercise capacity among children with CF and non-CF bronchiectasis over a two year period
Lung clearance index and exercise capacity among children with CF and non-CF bronchiectasis over a two year period
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CF 和非 CF 支气管扩张儿童两年内的肺清除指数和运动能力
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
J. Tsanakas
中科院分区：
文献类型：
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作者：
E. Hatziagorou;Petrina Vantsi;Vasiliki Avramidou;A. Kampouras;Fotios Kirvassilis;V. Georgopoulou;Maria Karailidou;J. Tsanakas
目的：比较支气管扩张儿童中 LCI 和运动能力评估的肺部疾病进展情况。方法：对 14 名稳定的 CF 患者和 13 名患有非 CF 支气管扩张且具有可比 FEV1 的稳定儿童进行了为期两年的 HRCT、最大增量心肺运动试验和多次呼吸冲洗 (MBW) 评估。结果：14 名 CF 患者（平均年龄 13.5 岁，平均 FEV1 = 80.1%）和 13 名非 CF 支气管扩张患者（平均年龄 = 13.05 岁，平均 FEV1 = 76.6%）参与了该研究。两组均存在运动受限的证据，平均峰值有氧能力 (VOpeak) 为预测值的 69.2%（CF 组）和 76.4%（非 CF 组），(p=0.321)。 CF 组的 VE/VO2 和 VE/VCO2 显着受损（p 结论：尽管 FEV1 值相当，但与非 CF 支气管扩张患者相比，CF 患者的运动能力和通气不均匀性似乎更受损。积极治疗可能会改善非 CF 支气管扩张患者的肺功能和运动能力，而 CF 患者的运动能力和通气不均匀性在两年内恶化。
Aim: To compare progression of lung disease assessed with LCI and exercise capacity among children with bronchiectasis. Method: Fourteen stable CF patients and 13 stable children with non-CF bronchiectasis and comparable FEV1 were assessed with HRCT, maximal incremental cardiopulmonary exercise testing and Multiple Breath Washout (MBW) over a two-year period. Results: Fourteen patients with CF (mean age 13.5 years, mean FEV1 =80.1%) and 13 patients with non-CF bronchiectasis (mean age =13.05 years, mean FEV1=76.6%), participated in the study. In both groups, there was evidence of exercise limitation, with mean Peak Aerobic Capacity (VOpeak) 69.2 % predicted (CF group) and 76.4 % (non CF group), (p=0.321). VE/VO2 and VE/VCO2 were significantly impaired in the CF group (p Conclusions: Despite comparable FEV1 values, patients with CF seem to have more impaired exercise capacity and ventilation inhomogeneity, compared to patients with non-CF bronchiectasis. Aggressive treatment may improve lung function and exercise capacity among patients with non-CF bronchiectasis, while exercise capacity and ventilation inhomogeneity deteriorate among patients with CF in a two year period.