Taurine increases hippocampal neurogenesis in aging mice
Taurine increases hippocampal neurogenesis in aging mice
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DOI：
10.1016/j.scr.2015.04.001
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发表时间：
2015-05-01
影响因子：
1.2
通讯作者：
Toni, Nicolas
中科院分区：
文献类型：
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作者：
Gebara, Elias;Udry, Florian;Toni, Nicolas
衰老与炎症增加和海马神经发生减少有关，这反过来可能导致认知障碍。牛磺酸是一种游离氨基酸，存在于许多饮食中，具有抗炎特性。虽然丰富的年轻的大脑中，牛磺酸浓度随年龄的减少可能是神经发生减少的基础。在这里，我们评估了牛磺酸对中年小鼠海马神经发生的影响。我们发现，牛磺酸通过激活静止干细胞增加齿状回细胞增殖，导致干细胞和中间神经祖细胞数量增加。牛磺酸对干/祖细胞增殖有直接影响，如在体外观察到的，并且还减少活化的小胶质细胞。此外，牛磺酸增加了新生神经元的存活，导致成年神经发生的净增加。总之，这些结果表明，牛磺酸增加了成年神经发生的几个步骤，并支持牛磺酸在脑老化背景下对海马神经发生的有益作用。(C)2015作者由爱思唯尔公司出版
Aging is associated with increased inflammation and reduced hippocampal neurogenesis, which may in turn contribute to cognitive impairment. Taurine is a free amino acid found in numerous diets, with anti-inflammatory properties. Although abundant in the young brain, the decrease in taurine concentration with age may underlie reduced neurogenesis. Here, we assessed the effect of taurine on hippocampal neurogenesis in middle-aged mice. We found that taurine increased cell proliferation in the dentate gyrus through the activation of quiescent stem cells, resulting in increased number of stem cells and intermediate neural progenitors. Taurine had a direct effect on stem/progenitor cells proliferation, as observed in vitro, and also reduced activated microglia. Furthermore, taurine increased the survival of newborn neurons, resulting in a net increase in adult neurogenesis. Together, these results show that taurine increases several steps of adult neurogenesis and support a beneficial role of taurine on hippocampal neurogenesis in the context of brain aging. (C) 2015 The Authors. Published by Elsevier B.V.