Postoperative Pain After Corneal Collagen Cross-Linking
Postoperative Pain After Corneal Collagen Cross-Linking
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DOI：
10.1097/ico.0b013e31824d6fe3
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发表时间：
2013-01-01
期刊：
影响因子：
2.8
通讯作者：
de Oliveira, Renan
中科院分区：
文献类型：
--
作者：
Ghanem, Vinicius C.;Ghanem, Ramon C.;de Oliveira, Renan
目的：评估角膜胶原交联（CXL）后的术后疼痛：方法：这项前瞻性研究包括135例进行性圆锥角膜谁在Sadalla阿明Ghanem眼科医院，Joinville，巴西进行CXL的178眼。术后使用30 mg可待因（Tylex）镇痛的需要和患者在术后第5天（PO）每天结束时对Wong-Baker FACES疼痛评定量表的主观评价评估疼痛。术后疼痛与最大角膜曲率阅读和中央角膜厚度的相关性，术前进行评估，进行了investigated.Results：平均患者年龄为23.38 +/- 5.86岁。平均（+/- SD）患者疼痛评分从手术当天（术后即刻，iPO）的2.78（+/- 1.68）显著降低（P < 0.05）至PO 5的0.12（+/- 0.46）。iPO、PO 1和PO 2时可待因药丸的平均数量分别为0.94、0.72和0.28，显示每个时间点均显著减少。统计学分析显示，年龄与PO 3和PO 4时的疼痛（患者年龄越小，疼痛越大）以及年龄与iPO时可待因片数之间存在显著相关性（P < 0.05）。平均整体疼痛和术前根尖角膜曲率（P = 0.546）和角膜厚度（P = 0.072）reading.Conclusions：CXL术后疼痛可以是激烈的，特别是在第3天，即使与积极的疼痛控制方案，但是，疼痛和镇痛的需要显着下降，连续每一天。疼痛与患者的年龄显著相关。
Purpose: To evaluate the postoperative pain after corneal collagen cross-linking (CXL).Methods: This prospective study included 178 consecutive eyes of 135 patients with progressive keratoconus who underwent CXL at Sadalla Amin Ghanem Eye Hospital, Joinville, Brazil. Pain was assessed postoperatively using the need for analgesia with 30 mg of codeine (Tylex) and by the patients' subjective evaluation on the Wong-Baker FACES Pain Rating Scale at the end of each day until postoperative day (PO) 5. Correlation of postoperative pain with maximum keratometric reading and central corneal thickness, which were assessed preoperatively, was investigated.Results: Mean patient age was 23.38 +/- 5.86 years. Mean (+/- SD) patient-scored pain decreased significantly (P < 0.05) from 2.78 (+/- 1.68) on the day of surgery (immediate postoperative period, iPO) to 0.12 (+/- 0.46) on PO5. The mean number of codeine pills was 0.94, 0.72, and 0.28 at iPO, PO1, and PO2, respectively, showing a significant decrease at each time point. Statistical analysis showed significant (P < 0.05) correlation between age and pain at PO3 and PO4 (the younger the patients the greater the pain) and between age and the number of codeine pills on iPO. There was no significant correlation between mean overall pain and preoperative apical keratometry (P = 0.546) and pachymetry (P = 0.072) readings.Conclusions: CXL postoperative pain can be intense, especially in the first 3 days, even with an aggressive pain control regimen; however, pain and the need for analgesia decreased significantly on each consecutive day. Pain was significantly correlated with the patient's age.