PRIMARY LYMPHOMA OF THE PROSTATE - GOOD OUTCOME WITH DOXORUBICIN-BASED COMBINATION CHEMOTHERAPY
PRIMARY LYMPHOMA OF THE PROSTATE - GOOD OUTCOME WITH DOXORUBICIN-BASED COMBINATION CHEMOTHERAPY
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DOI：
10.1016/s0022-5347(01)67330-0
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发表时间：
1995-06-01
影响因子：
6.6
通讯作者：
CABANILLAS, F
中科院分区：
文献类型：
--
作者：
SARRIS, A;DIMOPOULOS, M;CABANILLAS, F
1980年1月1日至1993年12月31日在我中心癌症中心就诊的3例患者中有3例诊断为前列腺癌，占原发淋巴瘤患者的0.1%，占原发前列腺癌患者的0.09%。3例患者均出现前列腺病，其中2例出现肾功能衰竭。经阿霉素为主的联合化疗后，3例患者均获得完全缓解，至少随访3年无病。我们的结果表明，原发性前列腺淋巴瘤并不一定与不良预后相关。对文献的回顾表明，报告的前列腺淋巴瘤预后较差的原因可能是治疗方法在当时是可以接受的，但按照目前的标准可能被认为是次优的。我们建议对所有前列腺癌患者进行彻底的分期，并根据疾病分期和组织学分类采用以阿霉素为基础的治疗方案。
Primary lymphoma of the prostate was diagnosed in 3 patients corresponding to 0.1% of those with previously untreated lymphoma and 0.09% of those with previously untreated prostatic malignancy presenting to our cancer center between January 1, 1980 and December 31, 1993. All 3 patients had prostatism at presentation that caused renal failure in 2. After treatment with doxorubicin-based combination chemotherapy appropriate for the stage and the specific histological subtype, all 3 patients achieved a complete remission and remained free of disease after a minimum followup of 3 years. Our results suggest that primary prostatic lymphoma is not necessarily associated with a poor outcome. Review of the literature suggests that the poor prognosis reported for prostatic lymphoma might be explained by treatment that was acceptable at the time but would be considered suboptimal by current criteria. We recommend thorough staging in all patients with prostatic lymphoma and treatment with a doxorubicin-based regimen according to disease stage and histological classification.