Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis
Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis
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DOI：
10.1371/journal.pone.0228852
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发表时间：
2020-02-13
期刊：
影响因子：
3.7
通讯作者：
Mimori, Tsuneyo
中科院分区：
文献类型：
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作者：
Murakami, Isao;Murakami, Kosaku;Mimori, Tsuneyo
目的探讨类风湿关节炎（RA）患者饮食习惯与疾病活动度的关系。方法本研究纳入京都大学类风湿关节炎管理联盟（KURAMA） 2015年队列中符合ACR/EULAR 2010分类标准的RA患者。采用22项食物频率问卷（FFQ）测量2015年京都大学类风湿关节炎管理联盟（KURAMA）单机构队列RA患者的饮食习惯。采用基于红细胞沉降率（DAS28-ESR）、简化疾病活动性指数（SDAI）、健康评估问卷（HAQ）、血清基质金属蛋白酶-3 （MMP-3）水平计算的疾病活动性评分、改善疾病的抗风湿药物（DMARDs）的使用、病程、类风湿因子、抗环葫芦化抗体和体重指数来检测RA的疾病活动性。对所有数据进行综合统计分析。结果从KURAMA队列中入组441例RA患者（81%为女性，平均年龄65岁，平均病程15年）。使用红细胞沉降率（DAS28-ESR）计算的平均疾病活动评分-28为2.7。单因素分析显示，蔬菜摄入频率与DAS28-ESR等疾病活动度指标呈统计学显著负相关(rho = -0.11, p
ObjectiveTo clarify the relationship between dietary habit and disease activity of rheumatoid arthritis (RA).MethodsThis study enrolled RA patients who met the ACR/EULAR 2010 classification criteria from Kyoto University Rheumatoid Arthritis Management Alliance (KURAMA) cohort in 2015. 22-item food frequency questionnaire (FFQ) was taken for the measurement of dietary habit in a single-institution cohort of RA (Kyoto University Rheumatoid Arthritis Management Alliance: KURAMA) in 2015. The disease activities of RA using the Disease Activity Score calculated based on the erythrocyte sedimentation rate (DAS28-ESR), Simplified Disease Activity Index (SDAI), Health Assessment Questionnaire (HAQ), and serum matrix metallo-proteinase-3 (MMP-3) level, the use of disease-modifying anti-rheumatic drugs (DMARDs), disease duration, rheumatoid factor, anti-cyclic citrullinated antibody, and body mass index were also examined. All of them were combined and statistically analyzed.Results441 RA patients (81% women; mean age 65 years; mean disease duration 15 years) were enrolled from the KURAMA cohort. Average Disease Activity Score-28 using the erythrocyte sedimentation rate (DAS28-ESR) was 2.7. Univariate analysis showed that intake frequency of vegetables had a statistically significant negative correlation with disease activity markers, such as DAS28-ESR (rho = -0.11, p