Life's Simple 7's Cardiovascular Health Metrics are Associated with Hispanic/Latino Neurocognitive Function: HCHS/SOL Results
Life's Simple 7's Cardiovascular Health Metrics are Associated with Hispanic/Latino Neurocognitive Function: HCHS/SOL Results
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DOI：
10.3233/jad-151125
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发表时间：
2016-01-01
影响因子：
4
通讯作者：
Mosley, Thomas H.
中科院分区：
文献类型：
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作者：
Gonzalez, Hector M.;Tarraf, Wassim;Mosley, Thomas H.
背景：据称西班牙裔/拉丁裔的神经认知能力下降和痴呆的风险增加。如果没有痴呆症治愈方法，就需要低成本、耐受性良好的公共卫生手段来缓解神经认知能力下降。 目的：我们研究了不同西班牙裔/拉丁裔人的神经认知与心血管健康 (CVH) 指标（Life's Simple 7；LS7）之间的关联。我们假设较高的 LS7 与更健康的大脑功能（神经认知表现）相关。方法：我们使用基线（2008-2011）西班牙社区健康研究/拉丁裔研究（HCHS/SOL；N=9,623；年龄 45-74 岁）来检查与 CVH LS7 分数相关的神经认知。结果：在年龄和性别调整模型中，一个单位的 LS7 分数增加（范围 = 0-14）与 B-SEVLT 总和（0.23 [p < 0.01]；范围 = 3-42）、B-SEVLT 回忆（0.12 [p < 0.01]；范围 = 0-15）、单词流利度（音素；0.46（p < 0.01）；范围 = 0-49）和数字符号的较高神经认知功能相关替代（0.49（p < 0.01）； 范围 = 0-83) 分别进行测试。换句话说，从最低 LS7 (0) 到最高 LS7 (14) 分数的变化对应于言语学习 (4.62) 和记忆 (2.24)、言语流畅性 (7.0) 和精神运动处理速度 (12) 的更高分数。在完全调整的模型中，相关性减弱，但仍具有统计学显着性。增量调整表明拉丁裔背景以及较小程度上的教育是造成明显衰减的主要因素。结论：我们发现中年和老年西班牙裔/拉丁裔中较高的神经认知功能与更好的 LS7 CVH 指标相关。神经认知功能与 LS7 之间的关联在神经认知衰退和痴呆的两个高危人群（即教育程度较低的女性和西班牙裔/拉丁裔）中最强。降低心血管疾病发病率和死亡率的公共卫生努力可能会给高危西班牙裔/拉丁裔带来额外的神经认知益处。
Background: Hispanics/Latinos are purportedly at increased risk for neurocognitive decline and dementias. Without dementia cures, low-cost, well-tolerated public health means for mitigating neurocognitive decline are needed.Objective: We examined associations between neurocognition and cardiovascular health (CVH) metrics (Life's Simple 7; LS7) among diverse Hispanics/Latinos. We hypothesized that higher LS7 would be associated with healthier brain function (neurocognitive performance).Methods: We used baseline (2008-2011) Hispanic Community Health Study/Study of Latinos (HCHS/SOL; N=9,623; ages 45-74 years) to examine neurocognition in relation to CVH LS7 scores.Results: In age and sex adjusted models, a one unit LS7 score increase (range = 0-14) was associated with higher neurocognitive function on the B-SEVLT sum (0.23 [p < 0.01]; range = 3-42), B-SEVLT recall (0.12 [p < 0.01]; range = 0-15), Word Fluency (phonemic; 0.46 (p < 0.01); range = 0-49), and Digit Symbol Substitution (0.49 (p < 0.01); range = 0-83) tests, respectively. Stated differently, a change from the minimum LS7 (0) to maximum LS7 (14) score corresponded to higher scores on verbal learning (4.62) and memory (2.24), verbal fluency (7.0), and psychomotor processing speed (12). In fully adjusted models the associations were attenuated, but remained statistically significant. Incremental adjustments indicated that Latino background and, to a lesser extent, education were primary contributors to the evinced attenuations.Conclusions: We found that higher neurocognitive functionwas associated with better LS7 CVH metrics among middle-aged and older Hispanics/Latinos. Associations between neurocognitive function and LS7 were strongest among two at-risk groups for neurocognitive decline and dementia, women and Hispanics/Latinos with lower education. Public health efforts to reduce cardiovascular disease morbidity and mortality may have additional neurocognitive benefits among at-risk Hispanics/Latinos.