Endogenous growth factors as cosmeceuticals
Endogenous growth factors as cosmeceuticals
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DOI：
10.1111/j.1529-8019.2007.00149.x
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发表时间：
2007-09
影响因子：
3.6
通讯作者：
R. Mehta;R. Fitzpatrick
中科院分区：
文献类型：
--
作者：
R. Mehta;R. Fitzpatrick
摘要：生长因子在逆转由时间和环境因素介导的皮肤衰老效应中发挥重要作用。细胞内和细胞外成分的过度氧化导致真皮中的胶原蛋白和弹性蛋白网络的破坏，并产生面部老化的效果。在多项临床研究中，局部应用人生长因子已被证明可减少皮肤老化的体征和症状，包括细纹和皱纹的统计学显著减少以及真皮胶原蛋白合成的增加。需要更多的双盲和对照研究来证实生长因子产品的初步临床效果，并需要建立更多的产品质量和稳定性控制。
ABSTRACT: Growth factors play an important role in reversing the effects of skin aging mediated by chronological and environmental factors. Excessive oxidation of intra‐ and extracellular components result in breakdown of collagen and elastin network in the dermis and produce the effect of facial aging. Topical application of human growth factors in multiple clinical studies has been shown to reduce the signs and symptoms of skin aging, including statically significant reduction in fine lines and wrinkles and increase in dermal collagen synthesis. More double‐blind and controlled studies are needed to confirm the preliminary clinical effects of growth factor products, and more controls on product quality and stability need to be established.