MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42
MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42
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MALAT1通过竞争性结合miR-1与cdc42诱导人乳腺癌细胞的迁移和侵袭
DOI：
10.1016/j.bbrc.2016.02.102
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发表时间：
2016-03-25
影响因子：
3.1
通讯作者：
Xi, Tao
中科院分区：
文献类型：
--
作者：
Chou, Jinjiang;Wang, Bingyu;Xi, Tao
竞争性内源性信使RNA（ceRNA）通过竞争性结合共同的microRNA（miRNAs）影响其他RNA的转录。在这项研究中，我们鉴定了长非编码RNA（lncRNA）MALAT 1可以作为细胞分裂周期42（cdc 42）3 'UTR的ceRNA通过miR-1诱导乳腺癌细胞的迁移和侵袭。我们发现miR-1直接结合MALAT 1和cdc 42的3 'UTR。进一步的研究表明，MALAT 1诱导乳腺癌细胞的迁移和侵袭，同时降低cdc 42的水平。我们的研究结果表明，MALAT 1通过竞争性结合miR-1影响cdc 42来调节乳腺癌细胞的迁移和侵袭。(C)2016 Elsevier Inc. All rights reserved.
Competitive endogenous messenger RNAs (ceRNAs) affect other RNAs transcription through competitively binding common microRNAs (miRNAs). In this study we identified long non-coding RNA (lncRNA) MALAT1 can function as a ceRNA of cell division cycle 42 (cdc42) 3'UTR in inducing migration and invasion of breast cancer cells via miR-1. We found that miR-1 bound both MALAT1 and cdc42 3'UTR directly. Further study showed that MALAT1 induced migration and invasion of breast cancer cells while reduced the level of cdc42. Our results suggest that MALAT1 regulated migration and invasion of breast cancer cells via affecting cdc42 through binding miR-1 competitively. (C) 2016 Elsevier Inc. All rights reserved.