Changes in frequencies of chromosomal aberrations and sister chromatid exchanges during confluent holding recovery in X-irradiated normal human diploid fibroblasts.
Changes in frequencies of chromosomal aberrations and sister chromatid exchanges during confluent holding recovery in X-irradiated normal human diploid fibroblasts.
复制标题
X射线照射的正常人二倍体成纤维细胞汇合保持恢复期间染色体畸变和姐妹染色单体交换频率的变化。
DOI：
10.1080/09553008514551651
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Little,JB
中科院分区：
文献类型：
--
作者：
Nagasawa,H;Little,JB
在X射线照射培养的人二倍体成纤维细胞的生存和细胞遗传学损伤的变化的时间过程中进行了研究之前释放密度抑制生长。在最初的2小时恢复期内，染色体畸变的频率迅速下降，同时生存率提高。姐妹染色单体交换（SCE）的频率增加，在此期间达到最大值的2小时，然后下降。这些变化进行了讨论，在类似的条件下，在啮齿动物细胞中的X射线引起的细胞遗传学损伤和恶性转化的有关以前的观察。
The time course of the changes in survival and cytogenetic damage was studied in X-irradiated cultures of human diploid fibroblasts before release from density-inhibition of growth. The frequency of chromosomal aberrations declined rapidly during the initial 2 h recovery interval in parallel with an enhancement in survival. The frequency of sister chromatid exchanges (SCE) increased during this interval reaching a maximum of 2 h, then declined. These changes are discussed in relation to previous observations on X-ray induced cytogenetic damage and malignant transformation in rodent cells under similar conditions.