Neonatal administration with dexmedetomidine does not impair the rat hippocampal synaptic plasticity later in adulthood
Neonatal administration with dexmedetomidine does not impair the rat hippocampal synaptic plasticity later in adulthood
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DOI：
10.1111/j.1460-9592.2012.03810.x
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发表时间：
2012-07
影响因子：
1.7
通讯作者：
K. Tachibana;Toshikazu Hashimoto;Rui Kato;Y. Uchida;R. Ito;K. Takita;Y. Morimoto
中科院分区：
文献类型：
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作者：
K. Tachibana;Toshikazu Hashimoto;Rui Kato;Y. Uchida;R. Ito;K. Takita;Y. Morimoto
背景和目的：右美托咪定(DEX)是一种选择性的α-2激动剂，由于其良好的性质，其在儿科实践中的应用正在扩大。为了阐明新生儿服用地塞米松对神经系统的长期影响，我们调查了新生儿服用地塞米松对海马区突触活动的长期影响。
Background and objective: The use of dexmedetomidine (DEX), a selective alpha‐2 agonist, in pediatric practice is expanding as a result of its desirable properties. To clarify the long‐term neurological consequences of neonatal administration of DEX, we investigated the long‐term effects of neonatal administration of DEX on hippocampal synaptic activity.