ULTRASTRUCTURE OF LEWY BODIES IN STELLATE GANGLION
ULTRASTRUCTURE OF LEWY BODIES IN STELLATE GANGLION
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DOI：
10.1007/bf00688674
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发表时间：
1976-01-01
影响因子：
12.7
通讯作者：
NORVILLE, RL
中科院分区：
文献类型：
--
作者：
FORNO, LS;NORVILLE, RL
在9例尸检患者的星状神经节上，用电镜检查了特发性帕金森病的特征性神经细胞包涵体路易体。发现了三种主要形式的路易体或路易体相关结构：罕见的丝状路易体，类似于中枢神经系统中的路易体；神经细胞突中的颗粒状路易体；异常的神经细胞突，充满异质物质。后2种形态以大而致密的核泡为主。2组无中枢神经系统路易体的帕金森病患者9例，无帕金森病患者17例，均未见上述异常。丝状路易体见于核周，被神经黑色素包围，而其他形式的路易体见于神经细胞突。线粒体包涵体主要存在于含神经黑色素的细胞中，但并非唯一存在于含神经黑色素的细胞中，与路易体形成或帕金森病无关。
The Lewy body, a characteristic nerve cell inclusion in idiopathic parkinsonism, was examined by EM in the stellate ganglion, obtained from 9 patients at autopsy. Three main forms of Lewy bodies or Lewy body-related structures were demonstrated: rare filamentous Lewy bodies, similar to Lewy bodies in the CNS; granular Lewy bodies in nerve cell processes; abnormal nerve cell processes, filled with heterogenous material. Large dense core vesicles were prominent in the last 2 forms. None of these abnormalities were found in 2 control groups consisting of 9 parkinsonism cases without CNS Lewy bodies, and 17 cases without parkinsonism. The filamentous Lewy body was found in the perikaryon and was surrounded by neuromelanin, whereas the other forms were seen in nerve cell processes. Mitochondrial inclusions, present mainly, but not exclusively, in neuromelanin-containing cells, were not related to Lewy body formation or to parkinsonism.