High Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chelsea, Massachusetts
High Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chelsea, Massachusetts
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DOI：
10.1093/infdis/jiaa579
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发表时间：
2020-12-15
影响因子：
6.4
通讯作者：
Iafrate, A. John
中科院分区：
文献类型：
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作者：
Naranbhai, Vivek;Chang, Christina C.;Iafrate, A. John
SARS-CoV-2抗体检测可以定量确定疾病的流行程度，这在高风险社区尤为重要。我们通过BioMedomics SARS-CoV-2联合IgM-IgG床旁侧流免疫测定法，对马萨诸塞州COVID-19疾病的震中切尔西的200名目前无症状的居民进行了匿名便利采样。血清阳性率为31.5%，其中IgM（+）IgG（+）17.5%，IgM（+）IgG（-）9.0%，IgM-IgG（+）5.0%。在200名参与者中，50.5%在前4周内没有报告任何症状，其中24.8%（25/101）为血清阳性，60%为IgM（+）IgG（-）。这些数据是迄今为止观察到的最高血清阳性率，突出了无症状感染的重大负担。
SARS-CoV-2 antibody testing allows quantitative determination of disease prevalence, which is especially important in high-risk communities. We performed anonymized convenience sampling of 200 currently asymptomatic residents of Chelsea, the epicenter of COVID-19 illness in Massachusetts, by BioMedomics SARS-CoV-2 combined IgM-IgG point-ofcare lateral flow immunoassay. The seroprevalence was 31.5% (17.5% IgM(+)IgG(+), 9.0% IgM(+)IgG(-), and 5.0% IgM-IgG(+)). Of the 200 participants, 50.5% reported no symptoms in the preceding 4 weeks, of which 24.8% (25/101) were seropositive, and 60% of these were IgM(+)IgG(-). These data are the highest seroprevalence rates observed to date and highlight the significant burden of asymptomatic infection.