TRANSCRIPTIONAL NOISE AND THE EVOLUTION OF GENE NUMBER
TRANSCRIPTIONAL NOISE AND THE EVOLUTION OF GENE NUMBER
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DOI：
10.1098/rstb.1995.0109
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发表时间：
1995-09-29
期刊：
影响因子：
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通讯作者：
TWEEDIE, S
中科院分区：
文献类型：
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作者：
BIRD, A;TWEEDIE, S
几个建议，以解释在进化过程中某些血统的复杂性明显增加。的建议（不按此顺序排列）是：（1）基因数量是生物复杂性的有效衡量标准;（2）基因数量在进化过程中不是连续增加的，而是以离散的步骤增加的;（3）两个最大的步骤发生在从原核生物到真核生物的过渡和从无脊椎动物到脊椎动物的过渡;（4）这些步骤是通过基因组中遗传信息管理方式的“系统性”改变而成为可能的;（5）沉默不合适的启动子的能力是基因数量的主要限制;（6）核小体的发明（也许还有核膜）促进了真核生物从原核生物祖先进化而来;（7）低密度甲基化在整个基因组中的扩散促进了脊椎动物从无脊椎动物祖先进化而来。
Several proposals are made to explain the apparent increase in complexity of certain lineages during evolution. The proposals (not made in this order) are: (1) that gene number is a valid measure of biological complexity; (2) that: gene number has not increased continuously during evolution, but has risen in discrete steps; (3) that two of the biggest steps occurred at the transition from prokaryotes to eukaryotes and the transition from invertebrates to vertebrates; (4) that these steps were made possible by 'systemic' changes in the way that genetic information is managed in the genome; (5) that the ability to silence inappropriate promoters is the primary limitation on gene number; (6) that the invention of nucleosomes (and perhaps the nuclear membrane) facilitated the evolution of eukaryotes from prokaryotic ancestors; (7) that the spread of low density methylation throughout the genome facilitated the evolution of vertebrates from invertebrate ancestors.