CDKN2BAS polymorphisms are associated with coronary heart disease risk a Han Chinese population.
CDKN2BAS polymorphisms are associated with coronary heart disease risk a Han Chinese population.
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DOI：
10.18632/oncotarget.12575
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发表时间：
2016-12-13
期刊：
影响因子：
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通讯作者：
Jin T
中科院分区：
文献类型：
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作者：
Zhao Q;Liao S;Wei H;Liu D;Li J;Zhang X;Yan M;Jin T
本研究的目的是确定CDKN 2BAS多态性是否与中国汉族人群冠心病（CHD）风险相关。在676名男性和465名女性中进行了8个SNP的基因分型。我们使用χ2检验和遗传模型分析来评估SNPs与CHD风险之间的关联。我们发现，rs 10757274与两名男性冠心病风险增加相关（等位基因G：OR = 1.30，95% CI：1.05-1.61，P = 0.018;共显性模型：P = 0.042;隐性模型：OR = 1.70，95% CI：1.10-2.62，P = 0.016;对数加性模型：OR = 1.34，95%CI：1.05-1.71，P = 0.019）和女性（优势模型：OR = 2.26，95%CI：1.28-3.99，P = 0.004）。此外，在隐性模型下，rs7865618与女性CHD风险增加8.10倍相关（OR = 8.10，95%CI：1.74-37.68，P = 0.006）。CDKN 2BAS基因单倍型AA（rs 10757274和rs 1333042）与男性冠心病发病风险降低相关（OR = 0.72，95%CI：0.55 ~ 0.95，P = 0.022）。
The goal of our study was to determine whether CDKN2BAS polymorphisms are associated with coronary heart disease (CHD) risk in a Han Chinese population. Eight SNPs were genotyped in 676 men and 465 women. We used χ2 tests and genetic model analyses to evaluate associations between the SNPs and CHD risk. We found that rs10757274 was associated with an increased risk of CHD in both men (allele G: Odds ratio [OR] = 1.30, 95% confidence interval [CI]: 1.05-1.61, P = 0.018; codominant model: P = 0.042; recessive model: OR = 1.70, 95% CI: 1.10-2.62, P = 0.016; log-additive model: OR = 1.34, 95% CI: 1.05-1.71, P = 0.019) and women (dominant model: OR = 2.26, 95% CI: 1.28-3.99, P = 0.004). In addition, rs7865618 was associated with an 8.10-fold increased risk of CHD in women under a recessive model (OR = 8.10, 95% CI: 1.74-37.68, P = 0.006). Interestingly, the haplotype AA (rs10757274 and rs1333042) of CDKN2BAS was associated with decreased the risk of CHD in men (OR = 0.72, 95% CI: 0.55 - 0.95, P = 0.022).