Viability of platelets following storage in the irradiated state. A pair‐controlled study
Viability of platelets following storage in the irradiated state. A pair‐controlled study
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辐照状态下储存后血小板的活力的配对对照研究。
DOI：
10.1046/j.1537-2995.1988.28588337334.x
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发表时间：
1988
期刊：
影响因子：
2.9
通讯作者：
S. Leitman
中科院分区：
文献类型：
--
作者：
Elizabeth J. Read;C. Kodis;Charles S. Carter;S. Leitman
血液制品的伽马辐照是推荐用于预防易感宿主输血后移植物抗宿主病的标准实践。我们研究了辐照对储存的浓缩血小板的影响，并评估了血小板是否可以在辐照状态下储存5天而对其活力无不良影响。使用配对对照设计，其中6名正常受试者中的每一名作为他或她自己的对照，我们比较了暴露于30戈伊并储存5天的血小板浓缩物与未经辐照仅储存5天的血小板浓缩物的体外储存特性和体内动力学。辐照对体外储存特性（血小板计数、平均血小板体积、pH值和白色细胞计数）或体内动力学（包括初始回收率和平均血小板存活率）无显著影响。使用多次击中模型，辐照浓缩物的初始回收率为49.6 ± 10.8%，平均血小板存活时间为5.6 ± 1.05天，而未辐照对照浓缩物的初始回收率和平均血小板存活时间分别为51.3 ± 13.0%和5.9 ± 0.50天。我们的结论是，高达30戈伊的血小板浓缩物的辐射没有影响他们在体内的恢复或生存，和血小板浓缩物储存前的辐射管理不干扰其临床疗效。
Gamma irradiation of blood products is a standard practice recommended for the prevention of posttransfusion graft‐versus‐host disease in susceptible hosts. We studied the effects of irradiation on stored platelet concentrates and evaluated whether platelets could be stored for 5 days in the irradiated state without adverse effects on their viability. Using a pair‐controlled design in which each of six normal subjects acted as his or her own control, we compared in vitro storage characteristics and in vivo kinetics of platelet concentrates exposed to 30 Gy and stored for 5 days with those of platelet concentrates simply stored for 5 days without irradiation. Irradiation had no significant effects on in vitro storage characteristics (platelet count, mean platelet volume, pH, and white cell count) or on in vivo kinetics, including initial recovery and mean platelet survival. Using the multiple‐hit model, initial recovery was 49.6 ± 10.8 percent, and mean platelet survival was 5.6 ± 1.05 days for irradiated concentrates, compared with 51.3 ± 13.0 percent and 5.9 ± 0.50 days, respectively, for the unirradiated control concentrates. We conclude that irradiation of platelet concentrates with up to 30 Gy has no effect on their in vivo recovery or survival, and that irradiation administered before storage of platelet concentrates does not interfere with their clinical efficacy.
DOI：
10.1016/0002-9343(82)90857-9
发表时间：
1982
期刊：
The American journal of medicine
影响因子：
--
作者：
vonFliedner,V;Higby,DJ;Kim,U
通讯作者：
Kim,U