Reference Ranges for Serum Concentrations of Lutropin (LH), Follitropin (FSH), Estradiol (E2), Prolactin, Progesterone, Sex Hormone-Binding Globulin (SHBG), Dehydroepiandrosterone Sulfate (DHEAS), Cortisol and Ferritin in Neonates, Children and Young Adults
Reference Ranges for Serum Concentrations of Lutropin (LH), Follitropin (FSH), Estradiol (E2), Prolactin, Progesterone, Sex Hormone-Binding Globulin (SHBG), Dehydroepiandrosterone Sulfate (DHEAS), Cortisol and Ferritin in Neonates, Children and Young Adults
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DOI：
10.1515/cclm.2002.202
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发表时间：
2002-12-01
影响因子：
6.8
通讯作者：
Ranke, Michael B.
中科院分区：
文献类型：
--
作者：
Elmlinger, Martin W.;Kuehnel, Werner;Ranke, Michael B.
这项研究的目的是建立儿童的参考范围（新生儿至年轻成人），血清促黄体生成素（LH）、促卵泡素（FSH）、雌二醇（E2）、孕酮、催乳素、性激素结合球蛋白（SHBG）、硫酸脱氢表雄酮（DHEAS）、皮质醇和铁蛋白，使用非同位素自动化学发光免疫分析系统，Immulite（R）（DPC）：检测了762名儿童（369名女性;年龄1天至19岁）的血清样品。其中，381例被归类为青春期。由于非正态分布，计算了每组的第2.5、50和97.5个中位数（中心95%区间）。统计学差异的参考范围进行了分析，就年龄，性别和性成熟的阶段。E2，催乳素，孕酮，DHEAS，皮质醇和铁蛋白的中位浓度在产后的前2周高于此后，最大的差异与催乳素，这表明在此期间高达27倍的高值。相反，在青春期开始之前，几乎没有观察到任何性别差异，所有分析物浓度保持相对恒定，除了SHBG在新生儿期后稳定增加外，随着性成熟的开始，女性性腺活动的增加包括LH和FSH的增加，伴随着E2，孕酮和催乳素的强烈增加。皮质醇在青春期增加到较小的程度。在男性中，除了DHEAS外，激素中位浓度的增加较小。铁蛋白的浓度在新生儿期较高，但在性成熟期没有变化。我们的研究结果与早期的研究一致。计算的参考区间可用于评估儿童的发育，特别是用于Immulite和Immulite 2000化学发光测定系统进行的测量。
The aim of this study was to establish reference ranges for children (neonates to young adults), for serum lutropin (LH), follitropin (FSH), estradiol (E2), progesterone, prolactin, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), cortisol and ferritin, using the nonisotopic, automated chemiluminescence immunoassay system, Immulite (R) (DPC).Serum samples from 762 children (369 female; age 1 day to 19 years) were examined. Of these, 381 were classified as pubertal. Due to non-normal distribution, the 2.5th, 50th and 97.5th percentiles (central 95% interval) were calculated for each group. Statistical differences between the reference ranges were analyzed with respect to age, sex and the stage of sexual maturation.The median concentrations of E2, prolactin, progesterone, DHEAS, cortisol and ferritin were higher during the first 2 weeks post-partum than thereafter, The largest difference was seen with prolactin, which showed up to 27-fold higher values during this period. In contrast, before the onset of puberty, hardly any sex difference was observed and all analyte concentrations remained relatively constant, apart from SHBG which increased steadily after the neonatal period.The increase of gonadal activity in females with the onset of sexual maturation included an increase in LH and FSH, which was accompanied by a strong increase in E2, progesterone and prolactin. Cortisol increased to a lesser extent during puberty. In males, the increase in the median concentrations of the hormones was smaller, except for DHEAS. The concentration of ferritin was high in the neonatal period but did not change during sexual maturation.Our findings agree with earlier studies. The calculated reference intervals can be used to assess the development of children, particularly for measurements performed by the Immulite and Immulite 2000 chemiluminescence assay systems.