Amygdala activity to fear and anger in healthy young males is associated with testosterone
Amygdala activity to fear and anger in healthy young males is associated with testosterone
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DOI：
10.1016/j.psyneuen.2008.11.007
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发表时间：
2009-06-01
影响因子：
3.7
通讯作者：
Habel, Ute
中科院分区：
文献类型：
--
作者：
Derntl, Birgit;Windischberger, Christian;Habel, Ute
神经影像学研究已经证实了外源性睾酮对杏仁核活动的调节作用。杏仁核是神经网络中的一个关键节点，是情绪感知和处理的基础，也与调节攻击性有关。然而，结果的正常范围内的睾酮水平的影响，外显情绪识别作为一个先决条件，社会交往和杏仁核激活在健康的年轻mates missing.Hence，我们进行了功能性MRI在3 T在一组21名健康的队友在外显情绪识别与协议专门优化，以可靠地检测杏仁核激活。我们观察到类似的杏仁核激活所有的情绪，没有任何影响的性别或侧。对恐惧的配偶面孔的反应时间与睾酮浓度呈负相关，而对其他情绪和中性表情没有显着影响。相关性分析显示，睾丸激素水平和杏仁核对恐惧和愤怒的面部表情的反应之间存在显着的正相关关系，但对其他表情则没有。因此，我们的研究结果表明，睾丸激素水平影响杏仁核的激活，也影响行为反应，特别是对健康年轻配偶的威胁相关的情绪。我们的结论是，这些研究结果增加了我们的理解情绪处理和神经内分泌因素的调制。(C)2008爱思唯尔有限公司保留所有权利。
Neuroimaging studies have documented modulation of the activity of the amygdala - a key node in the neural network underlying emotion perception and processing, and one that has also been associated with regulating aggression - by exogenous testosterone. However, results on the impact of normal range testosterone levels on explicit emotion recognition as a prerequisite for social interaction and amygdala activation in healthy young mates are missing.Hence, we performed functional MRI at 3 T in a group of 21 healthy mates during explicit emotion recognition with a protocol specifically optimized to reliably detect amygdala activation. We observed similar amygdala activation to all emotions presented without any effect of gender of poser or Laterally. Reaction times to fearful mate faces were found negatively correlated to testosterone concentration, while no significant effects emerged for other emotions and neutral expressions. Correlation analyses revealed a significant positive association between testosterone levels and amygdala response to fearful and angry facial expressions, but not to other expressions. Hence, our results demonstrate that testosterone levels affect amygdala activation and also behavioral responses particularly to threat-related emotions in healthy young mates. We conclude that these findings add to our understanding of emotion processing and its modulation by neuroendocrine factors. (C) 2008 Elsevier Ltd. All rights reserved.