Trifluoromethylthiolation of Masked Carbonyl Precursors: Reaction of Trifluoromethylsulfenyl Chloride With Enol Acetates

Trifluoromethylthiolation of Masked Carbonyl Precursors: Reaction of Trifluoromethylsulfenyl Chloride With Enol Acetates
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DOI：
10.1080/10426500211713
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发表时间：
2002-05
期刊：
Phosphorus, Sulfur, and Silicon and the Related Elements
影响因子：
--
通讯作者：
S. Munavalli;D. Rohrbaugh;F. R. Longo;H. Durst
S. Munavalli;D. Rohrbaugh;F. R. Longo;H. Durst
中科院分区：
其他
文献类型：
--
作者：
S. Munavalli;D. Rohrbaugh;F. R. Longo;H. Durst

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加入氟和含氟基团，如三氟甲基和三氟甲基硫基团，可大大提高母体产品的生物学特性和效力。本通报描述了掩膜羰基前体如烯醇乙酸酯的三氟甲基硫代化的结果、形成机制和所形成化合物的质谱表征。
Incorporation of fluorine and fluorine containing groups such as trifluoromethyl and trifluoromethylthio moieties considerably enhances the biological property and potency of the parent products. This communication describes the results of trifluoromethylthiolation of masked carbonyl precursors such as enol acetates, the mechanism of formation and mass spectral characterization of the compounds formed.