Dysconnectivity of the inferior frontal gyrus: Implications for an impaired self-other distinction in patients with schizophrenia
Dysconnectivity of the inferior frontal gyrus: Implications for an impaired self-other distinction in patients with schizophrenia
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DOI：
10.1016/j.pscychresns.2014.05.007
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发表时间：
2014-09-30
影响因子：
2.3
通讯作者：
Leube, Dirk T.
中科院分区：
文献类型：
--
作者：
Backasch, Bianca;Sommer, Jens;Leube, Dirk T.
精神分裂症中的自我障碍可能是由传出复制机制的失败引起的，传出复制机制将传出信号与传入信号进行比较，并减弱自我产生的运动的感觉结果。我们进行了一项功能磁共振成像研究，其中16例精神分裂症患者和16名健康匹配的对照进行了研究，同时进行有意和无意的连续手部运动在两个连续的实验。我们周期性地改变视觉反馈的延迟，以创造一个感觉运动的差异。专门为有意运动的激活模式的额下回（IFG）的患者是相反的控制：在时间一致的反馈和时间不一致的反馈过程中激活较少衰减。此外，错配检测网络内的几个功能连接（IFG与丘脑、壳核、内侧眶额皮质）受到影响。此外，活动的眶额皮质连接障碍与患者的自我障碍。我们讨论，在健康的个体IFG可能使自我和非自我之间的区别使用反馈的时间特性，而在患者中，这种感觉不匹配检测似乎被改变。此外，由于IFG的连接障碍，感觉和运动区域之间的传出和传入信号交换似乎受到影响。这可能会导致患者的自我监控缺陷，这种现象会导致自我干扰的出现。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Ego disturbances in schizophrenia might be caused by a failure of the efference copy mechanism, which compares efferent with reafferent signals and attenuates the sensory consequences of self-produced movements. We carried out a functional magnetic resonance imaging study in which 16 patients with schizophrenia and 16 healthy matched controls were studied while performing both intentional and unintentional continuous hand movements in two consecutive experiments. We periodically varied the delay of visual feedback to create a sensory-motor discrepancy. Exclusively for intentional movements the activation pattern of the inferior frontal gyrus (IFG) in patients was opposite to that of controls: less attenuated during time-congruent feedback and less activated during time-incongruent feedback. Additionally, several functional connections within the mismatch detection network (IFG with insula, putamen, medial orbitofrontal cortex) were affected. Also, activity of the dysconnected orbitofrontal cortex was correlated with ego disturbance in patients. We discuss that in healthy individuals the IFG might enable a distinction between self and non-self using time-characteristics of feedback, whereas in patients this sensory mismatch detection appears to be altered. Moreover, due to the dysconnectivity of the IFG, the efferent and reafferent signal exchange between perceptual and motor areas seems to be affected. This might cause self-monitoring deficits in patients, phenomena that contribute to the emergence of ego disturbances. (C) 2014 Elsevier Ireland Ltd. All rights reserved.