CONTROLLED TRIAL OF OXYGEN IN UNCOMPLICATED MYOCARDIAL-INFARCTION
CONTROLLED TRIAL OF OXYGEN IN UNCOMPLICATED MYOCARDIAL-INFARCTION
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DOI：
10.1136/bmj.1.6018.1121
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发表时间：
1976-01-01
影响因子：
105.7
通讯作者：
KENMURE, ACF
中科院分区：
文献类型：
--
作者：
RAWLES, JM;KENMURE, ACF
200名被认为患有心肌梗死的连续患者被纳入一项随机、双盲对照试验，在住院的前24小时内通过MC面罩给予氧气或空气。43例随后未证实心肌梗死的患者被排除在分析之外。其余空气组和氧气组相似，但氧气组的PaO2和血清天冬氨酸转氨酶水平显著较高。两组之间在死亡率、心律失常发生率、镇痛药使用或收缩时间间期方面没有显著差异，尽管在给予氧气的患者中发现窦性心动过速的发生率较高。似乎没有证据表明常规给氧对无并发症的心肌梗死有益。
Two-hundred consecutive patients thought to have suffered a myocardial infarction were admitted to a randomised, double-blind controlled trial of oxygen or air administered by MC mask throughout the first 24 hours in hospital. Forty-three patients in whom myocardial infarction was not subsequently confirmed were excluded from the analysis. The remaining air and oxygen groups were comparable except for a significantly higher PaO2 and serum aspartate aminotransferase level in the oxygen group. There was no significant difference in mortality, incidence of arrhythmias, use of analgesics, or systolic time intervals between the two groups, although a higher incidence of sinus tachycardia was found in those given oxygen. There appears to be no evidence of benefit from the routine administration of oxygen in uncomplicated myocardial infarction.