Location of a major susceptibility locus for familiar schizophrenia on chromosome 1q21-q22
Location of a major susceptibility locus for familiar schizophrenia on chromosome 1q21-q22
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DOI：
10.1126/science.288.5466.678
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发表时间：
2000-04-28
期刊：
影响因子：
56.9
通讯作者：
Bassett, AS
中科院分区：
文献类型：
--
作者：
Brzustowicz, LM;Hodgkinson, KA;Bassett, AS
精神分裂症是一种复杂的疾病，有大量证据支持其遗传病因。尽管如此，先前定位易感基因座的尝试主要产生了一些提示性的发现。对22个精神分裂症高发的大家系进行的全基因组精神分裂症易感基因座扫描，提供了与1号染色体（1q21 - q22）连锁的极显著证据，连锁似然对数（lod）得分最高为6.50。这一连锁结果应该提供足够的能力，以便对潜在的易感基因进行定位克隆。
Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings, A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity Logarithm of the likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to allow the positional cloning of the underlying susceptibility gene.