TIPE2 negatively regulates mycoplasma pneumonia-triggered immune response via MAPK signaling pathway.
TIPE2 negatively regulates mycoplasma pneumonia-triggered immune response via MAPK signaling pathway.
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TIPE2通过MAPK信号通路负调节肺炎支原体引发的免疫反应
DOI：
10.1038/s41598-017-13825-y
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发表时间：
2017-10-17
影响因子：
4.6
通讯作者：
Wang Q
中科院分区：
文献类型：
--
作者：
Zhang Y;Mei S;Zhou Y;Yang D;Pan T;Chen Z;Wang Q
过度的免疫反应在肺炎支原体感染的病理生理过程中起重要作用。肿瘤坏死因子-α诱导蛋白8样2（Tumor Necrosis Factor-α-induced protein 8-like 2，TIPE 2）是一种免疫应答的负调节因子。本研究旨在探讨TIPE 2在MP感染后的表达变化及其在免疫防御中的作用，并探讨其可能机制。检测MP感染后患者和体外巨噬细胞中TIPE 2的表达。我们进一步研究了MP感染后巨噬细胞中细胞因子的产生和丝裂原活化蛋白激酶（MAPK）信号转导功能。MP患者外周血单个核细胞（PBMCs）TIPE 2 mRNA表达显著降低，且与感染严重程度相关。因此，我们发现MP感染后巨噬细胞中TIPE 2表达下调。体外研究进一步表明TIPE 2通过抑制MAPK信号通路而抑制MP感染引起的炎症细胞因子的产生。这些发现为TIPE 2在抗MP免疫中的新功能及其可能的临床应用相关临床意义提供了证据。
Excessive immune responses played an important role in pathophysiology of mycoplasma pneumonia (MP) infection. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) is a negative regulator of immune response. This study investigated the expression change of TIPE2 and its role in immune defense against MP infection, as well as the underlying mechanisms. Expressions of TIPE2 both in patients and in macrophages in vitro after MP infection were measured. We further studied cytokine production and mitogen-activated protein kinase (MAPK) signaling function in macrophages with interfered expression of TIPE2 upon MP infection. A significant decrease of TIPE2 mRNA expression was observed in peripheral blood mononuclear cells (PBMCs) from MP patients, which was correlated with the severity of infection. Accordingly we found down-regulation of TIPE2 expression in macrophages after MP infection. In vitro study further suggested that TIPE2 jeopardized inflammatory cytokine production trigged by MP infection via inhibiting MAPK signaling pathway. These findings provided evidences of the novel function of TIPE2 in anti-MP immunity and its possible clinical utility related clinical significance.
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TIPE2 是一种新型免疫调节剂，可预防实验性中风。
影响因子：
4.8
作者：
Zhang, Yan;Wei, Xinbing;Yi, Fan
通讯作者：
Yi, Fan
TIPE2，先天性和适应性免疫的负调节因子，可维持免疫稳态。
影响因子：
64.5
作者：
Sun, Honghong;Gong, Shunyou;Chen, Youhai H.
通讯作者：
Chen, Youhai H.
影响因子：
9.7
作者：
Tarang, Shikha;Kumar, Sushil;Batra, Surinder K.
通讯作者：
Batra, Surinder K.
影响因子：
5.2
作者：
Izumikawa K
通讯作者：
Izumikawa K
影响因子：
2.2
作者：
Hwang, Mi-Hyun;Damte, Dereje;Park, Seung-Chun
通讯作者：
Park, Seung-Chun