BMP signaling in the development and regeneration of tooth roots: from mechanisms to applications.
BMP signaling in the development and regeneration of tooth roots: from mechanisms to applications.
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DOI：
10.3389/fcell.2023.1272201
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发表时间：
2023
影响因子：
5.5
通讯作者：
Sun, Hongchen
中科院分区：
文献类型：
--
作者：
Liu, Cangwei;Guo, Hao;Shi, Ce;Sun, Hongchen
短根畸形（Short root anomaly，SRA）沿着龋病、牙周炎、外伤等，可导致牙齿缺失，影响患者的身心健康。牙科植入物已被广泛用于牙齿修复;然而，与天然牙根相比，它们表现出一定的局限性。组织工程介导的牙根再生提供了一种策略，通过基于仿生原理再生生物工程牙根（生物根）来维持具有生理上更自然功能的牙齿。虽然之前的研究已经报道了牙根发育的过程，但具体的分子机制仍不清楚。骨形态发生蛋白（BMPs）家族是调节细胞活动的重要因子，并且参与几乎所有组织发育。近年来，人们利用转基因动物模型探索BMP信号在牙根发育中的作用机制，并为生物牙根再生提供更好的组织工程策略。本文就BMP信号在牙根发育和再生中的独特作用作一综述。
Short root anomaly (SRA), along with caries, periodontitis, and trauma, can cause tooth loss, affecting the physical and mental health of patients. Dental implants have become widely utilized for tooth restoration; however, they exhibit certain limitations compared to natural tooth roots. Tissue engineering-mediated root regeneration offers a strategy to sustain a tooth with a physiologically more natural function by regenerating the bioengineered tooth root (bio-root) based on the bionic principle. While the process of tooth root development has been reported in previous studies, the specific molecular mechanisms remain unclear. The Bone Morphogenetic Proteins (BMPs) family is an essential factor regulating cellular activities and is involved in almost all tissue development. Recent studies have focused on exploring the mechanism of BMP signaling in tooth root development by using transgenic animal models and developing better tissue engineering strategies for bio-root regeneration. This article reviews the unique roles of BMP signaling in tooth root development and regeneration.
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DOI：
10.1083/jcb.200106023
发表时间：
2001-12-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Hanyu A;Ishidou Y;Ebisawa T;Shimanuki T;Imamura T;Miyazono K
通讯作者：
Miyazono K
影响因子：
7.2
作者：
Hinck AP;Mueller TD;Springer TA
通讯作者：
Springer TA
DOI：
10.1073/pnas.0602558103
发表时间：
2006-05-16
影响因子：
11.1
作者：
Allendorph, George P.;Vale, Wylie W.;Choe, Senyon
通讯作者：
Choe, Senyon
影响因子：
4.8
作者：
Brown, MA;Zhao, QH;Choe, S
通讯作者：
Choe, S
影响因子：
10.5
作者：
Hata, A;Lagna, G;Hemmati-Brivanlou, A
通讯作者：
Hemmati-Brivanlou, A