Chemoenzymatic approaches to obtain chiral-centered selenium compounds
Chemoenzymatic approaches to obtain chiral-centered selenium compounds
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DOI：
10.1016/j.tet.2012.09.087
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发表时间：
2012-12-23
期刊：
影响因子：
2.1
通讯作者：
Andrade, Leandro H.
中科院分区：
文献类型：
--
作者：
Brondani, Patricia B.;Guilmoto, Nathalie M. A. F.;Andrade, Leandro H.
介绍了手性中心硒化合物的合成。这些有机硒化合物的对映选择性氧化进行了广泛的生物催化剂，包括Baeyer-Villiger单加氧酶，氧化还原酶含有土曲霉和脂肪酶（Cal-B）在氧化剂的存在下。最后，利用Cal-B介导的动力学拆分方法实现了对映体纯有机硒化合物的高效合成。(C)2012爱思唯尔有限公司保留所有权利。
The synthesis of chiral-centered selenium compounds is presented. Enantioselective oxidations of these organoselenium compounds were performed using a wide range of biocatalysts, including Baeyer-Villiger monooxygenases, oxidoreductases-containing Aspergillus terreus and lipase (Cal-B) in the presence of oxidants. Finally, efficient synthesis of enantiopure organoselenium compounds using a kinetic resolution approach mediated by Cal-B was achieved. (C) 2012 Elsevier Ltd. All rights reserved.