A PRIMATE MODEL FOR AGE-RELATED MACULAR DRUSEN
A PRIMATE MODEL FOR AGE-RELATED MACULAR DRUSEN
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DOI：
10.1136/bjo.76.1.11
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发表时间：
1992-01-01
影响因子：
4.1
通讯作者：
SHERWOOD, MB
中科院分区：
文献类型：
--
作者：
HOPE, GM;DAWSON, WW;SHERWOOD, MB
自1938年以来，加勒比灵长类动物研究中心（CPRC）一直将一群半自由放养的恒河猴隔离起来，并将其作为年龄相关性黄斑玻璃疣的模型进行研究。 在检查的群体动物中，57.7%的猴子和47.3%的眼睛有玻璃疣。 玻璃疣的患病率和严重程度与年龄的增长呈线性相关，并且在特定的母系（matrilines）中显著更高。 电生理学评估表明与玻璃疣相关的功能丧失。 CPRC雌性中玻璃疣的患病率几乎是雄性的两倍，而CPRC动物中的患病率通常似乎是美国大陆设施中猴的数倍。 有证据表明，终末期病变的频率也与人群相似。 CPRC母系猴似乎提供了迄今报道的人类年龄相关性黄斑玻璃疣的最佳模型。
A closed colony of semi-free-ranging rhesus monkeys maintained in isolation since 1938 by the Caribbean Primate Research Center (CPRC) is being studied as a model for age related macular drusen. Of examined colony animals 57.7% of the monkeys and 47.3% of their eyes have drusen. The prevalence and severity of drusen are linearly related to increasing age and are significantly higher in specific maternal lineages (matrilines). An electrophysiological estimate indicates loss of function associated with drusen. Prevalence of drusen in CPRC females is almost twice that of males, while the prevalence among CPRC animals in general appears to be several times that of monkeys from continental US facilities. Evidence suggests that the frequency of endstage lesions is also similar to that in human populations. The CPRC matriline monkeys appear to provide the best model yet reported for human age related macular drusen.