Cytokine-mediated bone destruction in rheumatoid arthritis.
Cytokine-mediated bone destruction in rheumatoid arthritis.
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DOI：
10.1155/2014/263625
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发表时间：
2014
影响因子：
4.1
通讯作者：
Ju JH
中科院分区：
文献类型：
--
作者：
Jung SM;Kim KW;Yang CW;Park SH;Ju JH
骨稳态包括骨形成和骨吸收，是维持人体足够骨量的重要过程。类风湿关节炎（Rheumatoid arthritis， RA）是一种以炎症和骨质流失为特征的自身免疫性疾病，可导致关节破坏和畸形，是骨稳态破坏的典型疾病。骨丢失和关节破坏是由促炎细胞因子和各种免疫细胞的免疫损伤介导的。骨与免疫之间的联系已被深入研究，并构成了骨免疫学的新兴领域。骨免疫学是一门研究骨骼和免疫系统相互作用的跨学科科学。骨免疫学的主要贡献者是骨效应细胞，如破骨细胞或成骨细胞，以及免疫细胞，特别是淋巴细胞和单核细胞。生理上，破骨细胞来源于免疫细胞，免疫细胞调节成骨细胞，反之亦然。诸如类风湿性关节炎之类的病理状况可能会影响这些相互作用，从而改变骨稳态，导致骨破坏的不利结果。在这篇综述中，我们描述了促炎细胞因子和免疫细胞在RA病理生理中的重要作用。
Bone homeostasis, which involves formation and resorption, is an important process for maintaining adequate bone mass in humans. Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and bone loss, leading to joint destruction and deformity, and is a representative disease of disrupted bone homeostasis. The bone loss and joint destruction are mediated by immunological insults by proinflammatory cytokines and various immune cells. The connection between bone and immunity has been intensely studied and comprises the emerging field of osteoimmunology. Osteoimmunology is an interdisciplinary science investigating the interplay between the skeletal and the immune systems. The main contributors in osteoimmunology are the bone effector cells, such as osteoclasts or osteoblasts, and the immune cells, particularly lymphocytes and monocytes. Physiologically, osteoclasts originate from immune cells, and immune cells regulate osteoblasts and vice versa. Pathological conditions such as RA might affect these interactions, thereby altering bone homeostasis, resulting in the unfavorable outcome of bone destruction. In this review, we describe the osteoclastogenic roles of the proinflammatory cytokines and immune cells that are important in the pathophysiology of RA.
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影响因子：
4.9
作者：
Adamopoulos IE;Chao CC;Geissler R;Laface D;Blumenschein W;Iwakura Y;McClanahan T;Bowman EP
通讯作者：
Bowman EP
影响因子：
5.4
作者：
Chen, Li;Wei, Xiao-Qing;Aeschlimann, Daniel
通讯作者：
Aeschlimann, Daniel
影响因子：
4
作者：
DeSelm, Carl J.;Takahata, Yoshifumi;Warren, Julia;Chappel, Jean C.;Khan, Taimur;Li, Xiaoxia;Liu, Caini;Choi, Yongwon;Kim, Youngmi Faith;Zou, Wei;Teitelbaum, Steven L.
通讯作者：
Teitelbaum, Steven L.
影响因子：
--
作者：
De Benedetti, Fabrizio;Rucci, Nadia;Teti, Anna
通讯作者：
Teti, Anna
影响因子：
158.5
作者：
Edwards, JCW;Szczepanski, L;Shaw, T
通讯作者：
Shaw, T