Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation
Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation
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DOI：
10.1016/j.expneurol.2008.05.008
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发表时间：
2008-09-01
影响因子：
5.3
通讯作者：
Aziz, T.
中科院分区：
文献类型：
--
作者：
Ray, N. J.;Jenkinson, N.;Aziz, T.
帕金森病的药物治疗方法是使用多巴胺替代药物，最近又通过刺激基底神经节核（例如丘脑底核 (STN)）来治疗。此手术后的深度记录显示，频率在 8 至 35 Hz 之间的过度活动（Brown 等人，2001 年；Kuhn 等人，2004 年；Priori 等人，2004 年）通过多巴胺治疗可减少，同时改善运动迟缓/僵硬，但不改善震颤（Kuhn 等人，2006 年）。研究还表明，多巴胺后运动症状的改善与 β 范围内的单个单位活性相关（Weinberger 等，2006）。我们记录了帕金森病 (PD) 患者在接受和停止多巴胺能药物治疗期间植入深部脑刺激电极的手术后丘脑底核的局部场电位 (LFP)。除了复制 Kuhn 等人的研究之外，我们还能够使用相同的患者来扩展 Weinberger 等人的研究。表明 LFP β 振荡活动与运动迟缓/强直的改善程度相关，但与多巴胺药物治疗后的震颤无关。我们还发现，在回归分析中刺激 STN 后，β 振荡活动的力量可以独特地预测运动迟缓/僵硬的改善，但同样不能预测震颤。然而，STN 刺激后的改善与 β 功率成反比，这可能反映了电极放置的准确性和/或具有最高水平 β 振荡活动的患者的 STN 刺激的限制。 (C) 2008 Elsevier Inc. 保留所有权利。
Parkinson's disease is treated pharmacologically with dopamine replacement medication and, more recently, by stimulating basal-ganglia nuclei such as the subthalamic nucleus (STN). Depth recordings after this procedure have revealed excessive activity at frequencies between 8 and 35 Hz (Brown et ad., 2001: Kuhn et al, 2004; Priori et al., 2004) that are reduced by dopamine therapy in tandem with improvements in bradykinesia/rigidity, but not tremor ( Kuhn et al., 2006). It has also been shown that improvements in motor symptoms after dopamine correlate with single Unit activity in the beta range (Weinberger et al., 2006). We recorded local field potentials (LFPs) from the subthalamic nucleus of patients with Parkinson's disease (PD) after surgery to implant deep brain stimulating electrodes while they were on and off dopaminergic medication. As well as replicating Kuhn et al., using the same patients we were able to extend Weinberger et al. to show that LFP beta oscillatory activity correlated with the degree of improvement in bradykinesia/ rigidity, but not tremor after dopamine medication. We also found that the power of beta oscillatory activity uniquely predicted improvements in bradykinesia/rigidity, but again not tremor, after stimulation of the STN in a regression analysis. However improvements after STN stimulation related inversely to beta power, possibly reflecting the accuracy of the electrode placement and/or the limits of STN stimulation in patients with the greatest levels of beta oscillatory activity. (C) 2008 Elsevier Inc. All rights reserved.