ENDOCRINE DISORDERS IN MEN INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS
ENDOCRINE DISORDERS IN MEN INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS
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DOI：
10.1016/0002-9343(88)90144-1
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发表时间：
1988-03-01
影响因子：
5.9
通讯作者：
POLK, BF
中科院分区：
文献类型：
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作者：
DOBS, AS;DEMPSEY, MA;POLK, BF
对70例人类免疫缺陷病毒（HIV）感染血清阳性的男性进行了性腺、肾上腺和甲状腺功能评估，这些男性临床分为无症状（n = 19）、艾滋病相关复合物（n = 9）或获得性免疫缺陷综合征（AIDS） （n = 42）。40名男性艾滋病患者中有20人（50%）性腺功能低下。两组的平均血清睾酮浓度为292 +-。70 ng/dl)和艾滋病(401 .+-。30 ng/dl)的男性明显低于无症状者（567 .+-）。49纳克/分升)或正常男性（608纳克/分升）。121毫微克/分升)。在这些性腺功能低下的男性中，24人中有18人（75%）患有促性腺功能低下症。8名性腺功能低下的男性中有7名（88%）在使用促性腺激素释放激素后，促性腺激素反应正常。性腺功能减退与淋巴细胞减少和体重减轻有关。通过促肾上腺皮质激素刺激评估，39例艾滋病患者中有36例（92%）的肾上腺皮质醇储备正常。除1例ARC患者游离甲状腺素指数低外，其他甲状腺功能指标均正常。总之，性腺功能减退在男性HIV感染中很常见，可能是第一个或最敏感的内分泌异常。
Gonadal, adrenal, and thyroid functions were evaluated in 70 men seropositive for human immunodeficiency virus (HIV) infection, clinically categorized as asymptomatic (n = 19), AIDS-related complex (ARC) (n = 9), or acquired immunodeficiency syndrome (AIDS) (n = 42). Twenty of 40 men (50 percent) with AIDS were hypogonadal. Mean serum testosterone concentrations in both ARC (292 .+-. 70 ng/dl) and AIDS (401 .+-. 30 ng/dl) men were significantly less than in asymptomatic (567 .+-. 49 ng/dl) or normal men (608 .+-. 121 ng/dl). Of these hypogonadal men, 18 of 24 (75 percent) had hypogonadotropic hypogonadism. Seven of eight hypogonadal men (88 percent) had a normal gonadotropin response to gonadotropin-releasing hormone administration. Hypogonadism correlated with lymphocyte depletion and weight loss. Adrenal cortisol reserve, evaluated by adrenocorticotropin stimulation, was normal in 36 of 39 patients (92 percent) with AIDS. Indices of thyroid function were normal with the exception of one ARC man with a low free thyroxine index. In conclusion, hypogonadism is common in men with HIV infection and may be the first or most sensitive endocrine abnormality.