Sugar sweetened beverages consumption and risk of coronary heart disease: A meta-analysis of prospective studies
Sugar sweetened beverages consumption and risk of coronary heart disease: A meta-analysis of prospective studies
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DOI：
10.1016/j.atherosclerosis.2014.01.037
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发表时间：
2014-05-01
期刊：
影响因子：
5.3
通讯作者：
Gu, Dongfeng
中科院分区：
文献类型：
--
作者：
Huang, Chen;Huang, Jianfeng;Gu, Dongfeng
目的：总结含糖饮料(SSB)摄入与冠心病发病风险的相关证据，为今后的相关研究提供领域标准。方法：应用PubMed、EMBASE、Cochrane图书馆数据库检索2013年2月以前的相关文献，并查阅参考文献列表。前瞻性研究包括不同类型的SSB消费的报告相对风险(RR)和95%可信区间(CI)的CHD。结果：在173,753名受试者中，有4项前瞻性研究涉及7396例冠心病病例，纳入Meta分析。SSB最高消费类别与最低SSB消费类别相比，CHD的合并RR(95%CI)为1.17(1.07-1.28)。分层分析表明男性有显著的相关性，但女性没有，合并RRS(95%CI)分别为1.17(1.05-1.29)和1.19(0.94-1.50)。在美国进行的研究中，CHD的合并RR为1.18(1.07-1.30)。此外，每天摄入一定量的SSB与CHD风险增加16%相关(RR：1.16，95%CI：1.10-1.23)。结论：我们对四项研究的荟萃分析表明，食用SSB可能会增加CHD的风险，尤其是在男性和美国人群中。然而，这一发现是基于有限的研究；进一步的研究是必要的，以批判性地评估这种关系。(C)2014年，爱思唯尔爱尔兰有限公司出版。
Objective: To summarize the evidence with respect to sugar sweetened beverages (SSBs) consumption and risk of coronary heart disease (CHD) and to recommend field standards for future analysis on this topic.Methods: We searched for articles published up to February 2013 through PubMed, EMbase, and Cochrane Library Database and reviewed reference list of the retrieved articles. Prospective studies with reported relative risks (RRs) with 95% confidence intervals (CIs) of CHD for different categories of SSBs consumption were included. Random-effects models were used to evaluate the associations by comparing the highest and lowest categories of SSBs consumption in relation to risk of CHD.Results: Four prospective studies with 7396 CHD cases among 173,753 participants were included in the meta-analysis. The pooled RR (95% CI) for CHD in the highest category of SSBs consumption in comparison with the lowest category of SSBs was 1.17 (1.07-1.28). Stratified analyses indicated a significant association for men but not for women, with pooled RRs (95% CI) of 1.17 (1.05-1.29) and 1.19 (0.94-1.50), respectively. For studies carried out in America, the pooled RR for CHD was 1.18 (1.07-1.30). Additionally, a one-severing per day increase in SSBs consumption was associated with a 16% increased risk of CHD (RR: 1.16, 95% CI: 1.10-1.23).Conclusion: Our meta-analysis of four studies suggests that consumption of SSBs may increase risk of CHD, especially among men and American populations. However, this finding was based on limited studies; further studies are warranted to critically evaluate the relationship. (C) 2014 Published by Elsevier Ireland Ltd.