The effects of amrinone on contractility, Ca2+ uptake and cAMP in smooth muscle.
The effects of amrinone on contractility, Ca2+ uptake and cAMP in smooth muscle.
复制标题
氨力农对平滑肌收缩力、Ca2 摄取和 cAMP 的影响。
DOI：
10.1016/0014-2999(80)90158-2
复制
发表时间：
1980
影响因子：
5
通讯作者：
C. Breemen
中科院分区：
文献类型：
--
作者：
K. Meisheri;R. Palmer;C. Breemen
Amrinone, a known positive inotropic agent in the heart, was found to cause a dose-dependent (10–100 μg/ml) inhibition of norepinephrine (NE) or high-K+-induced contractions of rabbit aorta. Amrinone also inhibited carbachol or high-K+-induced contractions of guinea-pig taenia coli. Neither total tissue45Ca uptake nor the rate of45Ca uptake induced by 80 mM K+in rabbit aorta was altered by pretreatment with amrinone. On the other hand, a similar pretreatment with amrinone inhibited NE (10−6or 10−5M) induced tissue45Ca uptake. Amrinone (100 μg/ml) caused about a 70% increase in cAMP concentration over resting levels. It is concluded that amrinone causes a nonspecific inhibition of smooth muscle contractility by acting probably at multiple sites to decrease the availability of Ca2+required for activation. One or more of these mechanisms may involve cAMP.
