Fundic Gland Polyps and Association with Proton Pump Inhibitor Intake: A Prospective Study in 1,780 Endoscopies
Fundic Gland Polyps and Association with Proton Pump Inhibitor Intake: A Prospective Study in 1,780 Endoscopies
复制标题
DOI：
10.1007/s10620-010-1493-x
复制
发表时间：
2011-06-01
影响因子：
3.1
通讯作者：
Alberto Viola, Luis
中科院分区：
文献类型：
--
作者：
Zelter, Adriana;Luis Fernandez, Jose;Alberto Viola, Luis
背景和目的 胃底腺息肉 (FGP) 是在因非相关适应症进行内窥镜检查时偶然发现的。一些作者提出与质子泵抑制剂（PPI）摄入量有关。我们的目的是确定它们的患病率以及与 PPI 摄入量的关系。方法我们前瞻性地研究了 2007 年 6 月至 2008 年 8 月期间在我们的门诊护理中心接受胃十二指肠内窥镜检查的 1,780 名患者。至少 12 个月期间的 PPI 摄入量、女性性别和年龄被统计评估为 FGP 存在的危险因素。然后对这些变量进行多元Logistic回归分析。结果 129例患者（7.2%）发现胃息肉，77例（4.33%）为FGP。五名没有可用组织学的患者被排除在危险因素评估之外。在 49 名患有 FGP 的患者 (63.6%) 和 264 名没有 FGP 的患者 (15.5%) 中检测到 PPI 摄入量 (P < 0.0001)。 59 名患有 FGP 的患者 (76.7%) 和 987 名未患有 FGP 的患者 (58.1%) 为女性 (P < 0.001)。患有 FGP 的患者的平均年龄为 58.91 +/- A 11.82 岁，未患有 FGP 的患者的平均年龄为 50.34 +/- A 15.04 岁（P < 0.0001）。这三个变量在多重模型中仍然显着： PPI 摄入量：P < 0.0001，OR 9.00 (95% CI 5.44-14.89)；女性：P = 0.0001，OR 2.95 (95% CI 1.69-5.15)；年龄：P = 0.001，OR 1.03 (95% CI 1.01-1.05)。 结论 在我们的人群中，FGP 的患病率很高。尽管女性性别和年龄也很重要，但 PPI 摄入量是与 FGP 存在相关的最强危险因素。
Background and Aims Fundic gland polyps (FGPs) are incidentally found when an endoscopy is performed for a non-related indication. Some authors suggested a relationship with proton pump inhibitor (PPI) intake. We aimed to determine their prevalence and association with PPI intake.Methods We prospectively studied 1,780 patients who underwent a gastroduodenal endoscopy at our ambulatory care center between June 2007 and August 2008. PPI intake during a period of at least 12 months, female gender and age were statistically evaluated as risk factors for the presence of FGPs. Then, a multiple logistic regression analysis was applied to these variables.Results Gastric polyps were found in 129 patients (7.2%) and 77 (4.33%) were FGPs. Five patients with no available histology were excluded for the assessment of risk factors. PPI intake was detected in 49 patients with FGPs (63.6%) and 264 without FGPs (15.5%) (P < 0.0001). Fifty-nine patients with FGPs (76.7%) and 987 without FGPs (58.1%) were women (P < 0.001). The mean age was 58.91 +/- A 11.82 years in patients with FGPs and 50.34 +/- A 15.04 years in patients without FGPs (P < 0.0001). The three variables remained significant in the multiple model: PPI intake: P < 0.0001, OR 9.00 (95% CI 5.44-14.89); female gender: P = 0.0001, OR 2.95 (95% CI 1.69-5.15); age: P = 0.001, OR 1.03 (95% CI 1.01-1.05).Conclusions In our population, the prevalence of FGPs was high. Although female gender and age were also significant, PPI intake was the strongest risk factor associated with the presence of FGPs.