In vivo and in vitro preparation of divinyl-132,173-cyclopheophorbide-a enol
In vivo and in vitro preparation of divinyl-132,173-cyclopheophorbide-a enol
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二乙烯基-132,173-环脱镁叶绿酸-a烯醇的体内和体外制备
DOI：
10.1016/j.bmcl.2018.02.015
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
H. Tamiaki
中科院分区：
文献类型：
--
作者：
Y. Kinoshita;M. Kayama;Y. Kashiyama;H. Tamiaki
二乙烯基-132，173-环脱镁叶绿酸-aenol是由二乙烯基-叶绿素-a在原生生物体内代谢产生的，在体外由二乙烯基-焦脱镁叶绿酸-a（二乙烯基-叶绿素衍生物之一）通过分子内环化反应制得。在CDCl_3中的~ 1H NMR谱表明，所得产物在溶液中仅以烯醇形式存在。二氢卟酚π-体系在C132和C173位的分子内环化影响了该类叶绿素衍生物的光学性质，包括烯醇的非荧光发射。
Divinyl-132,173-cyclopheophorbide-aenol wasin vivoproduced as a metabolite of divinyl-chlorophyll-aby protists andin vitroprepared by the intramolecular cyclization of methyl divinyl-pyropheophorbide-a, one of the divinyl-chlorophyll-aderivatives. The1H NMR spectra in CDCl3showed that the obtained product took exclusively its enol form in the solution. The intramolecular cyclization of chlorin π-system at the C132and C173positions affected the optical properties of such chlorophyll derivatives including the non-fluorescent emission of the enol.