Dual projections of gonadotropin releasing hormone containing neurons to the interpeduncular nucleus and to the vasculature in the female rat.
Dual projections of gonadotropin releasing hormone containing neurons to the interpeduncular nucleus and to the vasculature in the female rat.
复制标题
雌性大鼠中含有神经元的促性腺激素释放激素双重投射到脚间核和脉管系统。
DOI：
10.1016/0006-8993(91)91308-n
复制
发表时间：
1991
期刊：
影响因子：
2.9
通讯作者：
Jennes,L
中科院分区：
文献类型：
--
作者：
Jennes,L
促性腺激素释放激素（GnRH）的免疫荧光结合脚间核和脉管系统的逆行标记证实，在大鼠中，某些GnRH神经元从隔对角线带投射到脚间核。然而，大约一半的GnRH神经元也投射到开孔毛细血管，这可以通过外周注射氟金和中央注射罗丹明标记微球的摄取和逆行运输来证明。结果表明，GnRH的内分泌作用部分是由神经元发挥的，这些神经元同时投射到神经血管接触区和大脑中参与某些行为调节的区域。这表明某些GnRH神经元可以直接将内分泌事件与其他脑内事件偶联，如前凸行为的调节。
Immunofluorescence for gonadotropin releasing hormone (GnRH) in combination with retrograde labeling from the interpeduncular nucleus, as well as from the vasculature confirms that, in the rat, certain GnRH neurons project from the septum-diagonal band to the interpeduncular nucleus. However, about one half of these GnRH neurons also project to fenestrated capillaries as evidenced by uptake and retrograde transport of both peripherally injected Fluoro-Gold and centrally injected rhodamine labeled microspheres. The results indicate that the endocrine effects of GnRH are exerted in part by neurons which simultaneously project to neurohemal contact zones and to areas in the brain which are involved in the regulation of certain behaviors. It is suggested that certain GnRH neurons can directly couple endocrine events with other intracerebral events, such as regulation of lordosis behavior.