Biomedical interfaces: titanium surface technology for implants and cell carriers.
Biomedical interfaces: titanium surface technology for implants and cell carriers.
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DOI：
10.2217/17435889.1.4.449
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发表时间：
2006-12
期刊：
影响因子：
5.5
通讯作者：
M. Schuler;D. Trentin;M. Textor;S. Tosatti
中科院分区：
文献类型：
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作者：
M. Schuler;D. Trentin;M. Textor;S. Tosatti
钛及其合金已成为生物医学应用的关键材料，主要是由于它们与人体组织的相容性和它们的机械强度。表面形貌对细胞和组织反应的影响在过去已经被广泛研究，而（生物）化学表面改性及其与设计的形貌的组合在很大程度上仍然未被探索。以下报告描述了基于生物学原理用于或旨在修饰钛表面的一些策略，重点是超薄仿生吸附层。这种方法背后的愿景之一是为患者实现植入后改善的愈合和整合反应，特别是为患有缺陷的患者，例如糖尿病或骨质疏松症，这两种疾病在上个世纪在我们的社会中急剧增加。
Titanium and its alloys have become key materials for biomedical applications, mainly owing to their compatibility with human tissues and their mechanical strength. Effects of surface topography on cell and tissue response have been investigated extensively in the past, while (bio)chemical surface modification and its combination with designed topographies have remained largely unexplored. The following report describes some of the strategies used or intended to modify titanium surfaces, based on biological principles, with a focus on ultrathin biomimetic adlayers. One of the visions behind such approaches is to achieve improved healing and integration responses after implantation for patients, especially for those suffering from deficiencies, for example, diabetes or osteoporosis, two diseases that have increased drastically in our society during the last century.