Perspectives of injectable long acting antiretroviral therapies for HIV treatment or prevention: understanding potential users' ambivalences
Perspectives of injectable long acting antiretroviral therapies for HIV treatment or prevention: understanding potential users' ambivalences
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DOI：
10.1080/09540121.2020.1742869
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发表时间：
2020-03-19
影响因子：
1.7
通讯作者：
Slama, Laurence
中科院分区：
文献类型：
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作者：
Carillon, Severine;Gallardo, Lucille;Slama, Laurence
最近的临床试验数据表明，每4周或8周注射一次长效抗逆转录病毒治疗（LA-ART）可能成为治疗或预防艾滋病毒的另一种选择。我们研究的目的是通过个体的治疗过程和他们与ART的独特历史，探索对这种新的给药模式的看法和潜在用户的观点。2018年至2019年期间，在法国巴黎的两所大学医院进行了一项定性研究。对15名病毒学控制的艾滋病毒感染者（PLWH）和13名接受暴露前预防（PrEP）治疗至少6个月的男性进行了深入访谈。访谈集中在抗逆转录病毒治疗的日常经验，被记录、转录，并使用主题内容分析进行分析。收集的话语围绕着三个新兴的关注点：社会、物质和实验。每一种担忧都被认为是矛盾的，被怀疑和希望所平衡。它揭示了每个人与其艾滋病毒治疗或PrEP之间关系的复杂性，从而平衡了临床试验中报告的可注射的LA-ART普及程度。这种新的给药模式可能是一些PLWH和PrEP使用者的合适选择，与口服途径相比，这是一种“简化”。它为根据个人生活“定制”的art治疗打开了一扇窗。
Recent clinical trial data showed that injectable long-acting antiretroviral treatment (LA-ART) every four or eight weeks could become an alternative option for HIV treatment or prevention. The purpose of our study was to explore perceptions and potential users' points of views of this new mode of administration through individuals' therapeutic itinerary and their singular history with ART. Between 2018 and 2019, a qualitative study was conducted in two University Hospitals in Paris, France. In-depth interviews were conducted with 15 virologically controlled People Living with HIV (PLWH) and 13 men on pre-exposure prophylaxis (PrEP) for at least six months. Interviews, focused on the daily experience with ART, were recorded, transcribed, and analyzed using thematic content analysis. Collected discourses were organized around three emergent concerns: social, material and experimental. Each of these concerns was perceived as ambivalent, balanced by skepticism and hope. It revealed the complexity of each individual's relationship to their HIV treatment or PrEP, leading to balance the injectable LA-ART popularity reported within clinical trials. This new mode of administration may be a suitable alternative for some PLWH and PrEP users, a "simplification" compared to the oral route. It opens a window for "customizable" ART-treatment according to individuals' lives.