NAIP inflammasomes give the NOD to bacterial ligands.

NAIP inflammasomes give the NOD to bacterial ligands.
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NAIP 炎症小体将 NOD 赋予细菌配体。

DOI:
10.1016/j.it.2014.10.002
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发表时间:
2014
影响因子:
16.8
通讯作者:
Miao,EdwardA
Miao,EdwardA
中科院分区:
医学1区
文献类型:
--
作者:
Maltez,VivienI;Miao,EdwardA

文献摘要

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NLR是一种先天免疫感受器,可以监测细胞质隔间的神圣性。在最近发表在《分子细胞》上的一篇论文中,Tenthoreve al。揭示了在NAIPS的寡聚结构域区域内的新的配体感测界面,而不是像预期的那样在富含亮氨酸的重复序列内。
NLRs are innate immune sensors that monitor the sanctity of the cytosolic compartment. In a recent paper inMolecular Cell, Tenthoreyet al. reveal a novel ligand-sensing interface within regions of the oligomerization domain of the NAIPs, rather than within the leucine-rich repeats, as was anticipated.