EXPRESSION OF 2 T-CELL RECEPTOR-ALPHA CHAINS - DUAL RECEPTOR T-CELLS
EXPRESSION OF 2 T-CELL RECEPTOR-ALPHA CHAINS - DUAL RECEPTOR T-CELLS
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DOI：
10.1126/science.8211163
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发表时间：
1993-10-15
期刊：
影响因子：
56.9
通讯作者：
LANZAVECCHIA, A
中科院分区：
文献类型：
--
作者：
PADOVAN, E;CASORATI, G;LANZAVECCHIA, A
虽然许多T细胞携带两个符合读框的V（alpha）重排，但两个V（alpha）重排的产物从未同时显示在正常细胞的表面上。使用V（alpha）2、V（alpha）12和V（alpha）24的单克隆抗体，多达三分之一的成熟T细胞表达两条V（alpha）链，作为两种功能性和独立的T细胞受体（TCR）的一部分。因此，“一个细胞，一个受体”规则不适用于大的α T细胞亚群。属于该双TCR亚群的细胞可以比具有单一受体的细胞对更宽范围的抗原具有特异性，这对于自身免疫和同种异体反应性可能是重要的。
Although many T cells carry two in-frame V(alpha) rearrangements, the products of both V(alpha) rearrangements have never been shown simultaneously on the surface of normal cells. With the use of monoclonal antibodies to V(alpha)2, V(alpha)12, and V(alpha)24, up to one-third of mature T cells expressed two V(alpha) chains as part of two functional and independent T cell receptors (TCRs). Thus, the ''one cell, one receptor'' rule does not apply to a large subset of alphabeta T cells. Cells that belong to this dual TCR subset may be specific for a broader range of antigens than cells with a single receptor, which may be important for autoimmunity and alloreactivity.