The Columbia University Single-Ion Microbeam
The Columbia University Single-Ion Microbeam
复制标题
哥伦比亚大学单离子微束
作者：
G. Randers;C. Geard;G. Johnson;C. Elliston;D. Brenner
摘要Randers-Pehrson，G.，吉亚德角R.，约翰逊，G.，埃利斯顿角D.和Brenner，D.哥伦比亚大学单离子微束。Radiat. Res. 156，210-214（2001）。在哥伦比亚大学放射学研究加速器装置上已经建造了一个单离子微束装置。该系统旨在将货车de Graaff加速器产生的限定数量的氦或氢离子（LET范围为30至220 keV/μm）输送到比在薄塑料膜上培养的人类细胞核更小的区域。光束由一对激光钻孔孔准直，形成光束线出口。一个集成的计算机控制程序定位细胞并将其定位以进行照射。我们提出的微束设施，包括准直器，硬件，控制程序，和各种协议的描述。沿着讨论了对瞄准和定位精度的各种贡献以及我们对未来发展的计划。外部用户的射束时间通常是可用的（参见www.raraf.org）。
Abstract Randers-Pehrson, G., Geard, C. R., Johnson, G., Elliston, C. D. and Brenner, D. J. The Columbia University Single-Ion Microbeam. Radiat. Res. 156, 210–214 (2001). A single-ion microbeam facility has been constructed at the Columbia University Radiological Research Accelerator Facility. The system was designed to deliver defined numbers of helium or hydrogen ions produced by a van de Graaff accelerator, covering a range of LET from 30 to 220 keV/μm, into an area smaller than the nuclei of human cells growing in culture on thin plastic films. The beam is collimated by a pair of laser-drilled apertures that form the beam-line exit. An integrated computer control program locates the cells and positions them for irradiation. We present details of the microbeam facility including descriptions of the collimators, hardware, control program, and the various protocols available. Various contributions to targeting and positioning precision are discussed along with our plans for future developments. Beam time for outside users is often available (see www.raraf.org).
DOI：
10.1073/pnas.94.8.3765
发表时间：
1997-04-15
影响因子：
11.1
作者：
Hei, TK;Wu, LJ;RandersPehrson, G
通讯作者：
RandersPehrson, G
DOI：
10.1073/pnas.030420797
发表时间：
2000-02-29
影响因子：
11.1
作者：
Zhou, HN;Randers-Pehrson, G;Hei, TK
通讯作者：
Hei, TK
DOI：
10.1073/pnas.96.9.4959
发表时间：
1999-04-27
影响因子：
11.1
作者：
Wu, LJ;Randers-Pehrson, G;Hei, TK
通讯作者：
Hei, TK