REGIONAL OBSTETRIC ANESTHESIA AND NEWBORN BEHAVIOR - A REANALYSIS TOWARD SYNERGISTIC EFFECTS
REGIONAL OBSTETRIC ANESTHESIA AND NEWBORN BEHAVIOR - A REANALYSIS TOWARD SYNERGISTIC EFFECTS
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DOI：
10.1111/j.1467-8624.1982.tb03442.x
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发表时间：
1982-01-01
影响因子：
4.6
通讯作者：
BRAZELTON, TB
中科院分区：
文献类型：
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作者：
LESTER, BM;ALS, H;BRAZELTON, TB
对54例足月健康新生儿在出生后第1、2、3、4、5、7、10天进行Braselton新生儿行为评定量表测试。根据4个变量计算单独的药物因素得分：从第一次和最后一次给药到给药的时间，不同药物的数量，以及药物给药。为了确定药物和其他产科因素对新生儿行为的相加效应，采用药物组和药物因素评分加上产程、产次和体重指数进行一系列多元回归分析，以预测每一天的Braselton量表集群评分。在第二组多元回归中，这些变量被用来预测婴儿在7天内的行为改变率，这是通过布拉泽顿量表集群得分的斜率来估计的。预测变量的组合效应显著解释了新生儿行为变异的10%-28%。人们假设，低水平药物的影响是微妙的，但当结合其他可能增强药物效应的因素进行药物效应研究时，可能会被掩盖。
The Brazelton Neonatal Behavioral Assessment Scale was administered to 54 term, healthy infants on days 1, 2, 3, 4, 5, 7 and 10. Infants were divided into 8 groups of maternal obstetrical medication. A separate drug factor score was computed from 4 variables: time from first and last drug administration to delivery, number of different drugs, and drug administrations. To determine the additive effects of drug and other obstetric factors on neonatal behavior, the drug group and drug factor score plus length of labor, parity and the ponderal index were used in a series of multiple regression analyses to predict Brazelton scale cluster scores on each day. In a 2nd set of multiple regressions, these variables were used to predict the infant''s rate of behavioral change as estimated by the slopes of the Brazelton scale cluster scores across the 7 days. The combined effect of the predictor variables significantly explained 10-28% of the variance in neonatal behavior. It was hypothesized that the effects of low levels of medication are subtle but may be unmasked when medication effects are studied in combination with other factors that may potentiate drug effects.