Fertility preservation in women with cancer.
Fertility preservation in women with cancer.
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DOI：
10.1016/s0140-6736(14)60834-5
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发表时间：
2014-10-04
期刊：
影响因子：
168.9
通讯作者：
Woodruff, Teresa K.
中科院分区：
文献类型：
--
作者：
De Vos, Michel;Smitz, Johan;Woodruff, Teresa K.
年轻癌症妇女长期存活率的提高以及生殖医学和低温生物学的进步，最终导致人们对癌症女孩和年轻妇女的生育力保存方法越来越感兴趣。目前的数据表明，年轻的癌症患者应尽快转介生育力保护咨询，以帮助他们应对过程。虽然新的发展，包括卵母细胞玻璃化冷冻和卵母细胞体外成熟的临床应用，导致在辅助生殖方案的合理的成功率，这些技术在生育力保存的设置经验是在其起步阶段。希望这些和其他方法，其中一些仍然被认为是实验性的（例如，卵巢组织冷冻保存，对性腺毒性药物的药物保护，体外卵泡生长和卵泡移植）将在未来十年内得到优化和建立。揭开激活和抑制卵泡生长的复杂机制不仅将扩大对数千名被诊断患有癌症的妇女的护理，而且还将为数百万因衰老而面临生殖健康下降的妇女提供护理。
Enhanced long-term survival rates of young women with cancer and advances in reproductive medicine and cryobiology have culminated in an increased interest in fertility preservation methods in girls and young women with cancer. Present data suggest that young patients with cancer should be referred for fertility preservation counselling quickly to help with their coping process. Although the clinical application of novel developments, including oocyte vitrification and oocyte maturation in vitro, has resulted in reasonable success rates in assisted reproduction programmes, experience with these techniques in the setting of fertility preservation is in its infancy. It is hoped that these and other approaches, some of which are still regarded as experimental (eg, ovarian tissue cryopreservation, pharmacological protection against gonadotoxic agents, in-vitro follicle growth, and follicle transplantation) will be optimised and become established within the next decade. Unravelling the complex mechanisms of activation and suppression of follicle growth will not only expand the care of thousands of women diagnosed with cancer, but also inform the care of millions of women confronted with reduced reproductive fitness because of ageing.