Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging
Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging
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DOI：
10.1117/1.2400910
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发表时间：
2006-11-01
影响因子：
3.5
通讯作者：
Boas, David A.
中科院分区：
文献类型：
--
作者：
Huppert, Theodore J.;Hoge, Rick D.;Boas, David A.
类似于功能磁共振成像（fMRI），扩散光学成像（DOI）是一种非侵入性的方法，用于测量脑内血红蛋白水平的局部变化。当结合功能磁共振成像方法，多模态方法可以提供一个综合的角度对生物物理学，解剖学和生理学的基础上的每一个成像模式。为了正确解释这些研究，必须进行对照实验来测试两种模式的一致性。在这里，我们比较DOI与血氧水平依赖性（BOLD）和动脉自旋标记fMRI为基础的方法，以探讨这两种方法记录的响应幅度的空间一致性。而不是通过正则化，断层重建创建光学图像，我们项目的fMRI图像到光学测量空间使用光学前向问题。我们报告了fMRI-BOLD反应与光学测量的脱氧血红蛋白之间的统计学相关性（R = 0.71，p = 1 × 10（-7）），而BOLD与氧合血红蛋白或总血红蛋白测量之间的统计学相关性（分别为R = 0.38，p = 0.04，竖线0.37，p = 0.05）。类似地，我们发现ASL测量的血流量与光学测量的总血红蛋白和氧合血红蛋白之间的相关性（分别为R = 0.73，p = 5 X 10（-6）和R = 0.71，p = 9 X 10（-6））比流量与脱氧血红蛋白的空间相关性（R = 0.26，p = 0.10）更强。(c)2006年，由光学仪器工程师协会（Society of Photo-Optical Instrumentation Engineers）主办。
Akin to functional magnetic resonance imaging (fMRI), diffuse optical imaging (DOI) is a noninvasive method for measuring localized changes in hemoglobin levels within the brain. When combined with fMRI methods, multimodality approaches could offer an integrated perspective on the biophysics, anatomy, and physiology underlying each of the imaging modalities. Vital to the correct interpretation of such studies, control experiments to test the consistency of both modalities must be performed. Here, we compare DOI with blood oxygen level-dependent (BOLD) and arterial spin labeling fMRI-based methods in order to explore the spatial agreement of the response amplitudes recorded by these two methods. Rather than creating optical images by regularized, tomographic reconstructions, we project the fMRI image into optical measurement space using the optical forward problem. We report statistically better spatial correlation between the fMRI-BOLD response and the optically measured deoxyhemoglobin (R = 0.71, p = 1 X 10(-7)) than between the BOLD and oxyhemoglobin or total hemoglobin measures (R = 0.38, p = 0.04 vertical bar 0.37, p = 0.05, respectively). Similarly, we find that the correlation between the ASL measured blood flow and optically measured total and oxyhemoglobin is stronger (R = 0.73, p = 5 X 10(-6) and R = 0.71, p = 9 X 10(-6), respectively) than the flow to deoxyhemoglobin spatial correlation (R = 0.26, p = 0.10). (c) 2006 Society of Photo-Optical Instrumentation Engineers.