Inner ear disturbances following inoculation of endotoxin into the middle ear.
Inner ear disturbances following inoculation of endotoxin into the middle ear.
复制标题
内毒素接种到中耳后引起内耳紊乱。
作者：
O. Spandow;M. Anniko;S. Hellström
Inner ear function was assessed by a frequency-specific (+/-100 Hz) auditory brainstem response (ABR) technique after a single instillation of a suspension of purified E. coli lipopolysaccharide in sterile water into the round window (RW) niche in rats. Instillation of endotoxin caused a transient concentration and tonotopically dependent dysfunction of the inner ear. The largest threshold impairment occurred in the high-frequency region anatomically located close to the RW. At 31.5 kHz the threshold impairment persisted throughout the study. Morphologic damage to the inner ear was not detected at the light microscopic level when using serial sections from decalcified specimens. Our study supports the clinical hypothesis that remnants of non-viable bacteria such as endotoxins, when trapped in the middle ear, can promote middle ear effusion and dysfunction of the inner ear.
抗原诱导的中耳炎中圆窗膜对人血清白蛋白的通透性。
影响因子：
2.5
作者：
Hamaguchi,Y;Morizono,T;Juhn,SK
通讯作者：
Juhn,SK