Prefrontal-thalamic-cerebellar gray matter networks and executive functioning in schizophrenia
Prefrontal-thalamic-cerebellar gray matter networks and executive functioning in schizophrenia
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DOI：
10.1016/j.schres.2007.01.029
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发表时间：
2007-07-01
影响因子：
4.5
通讯作者：
Spalletta, Gianfranco
中科院分区：
文献类型：
--
作者：
Rusch, Nicolas;Spoletini, Ilaria;Spalletta, Gianfranco
目的：执行功能差是精神分裂症的核心缺陷，与额叶改变有关。我们的目的是确定(1)精神分裂症患者前额叶脑区体积减少与执行功能障碍有关；(2)在第一次分析中确定的与前额叶区域相关的大脑区域，从而检测到与执行功能相关的更广泛的体积网络。方法：招募53例精神分裂症门诊患者和62例健康对照者，年龄、性别和利手性相匹配。在1.5特斯拉扫描仪上获取高分辨率图像，并在SPM5（统计参数映射，英国伦敦大学学院）中使用基于体素的形态测量法分析区域灰质和白质体积。使用威斯康辛卡片分类测验（WCST）评估执行功能。结果：与30名WCST表现良好的患者相比，21名执行功能差的患者表现出背外侧前额叶和前扣带灰质体积的减少，其中左背外侧前额叶皮层的影响最大。在控制了整体认知功能、言语注意力持续时间、阴性症状、疾病持续时间和教育等可能的混杂影响后，左背外侧前额叶灰质体积预测了WCST的表现。在这一区域，两组患者的灰质都少于健康对照组。左背外侧前额叶灰质体积与前额叶背侧、扣带前部和顶叶灰质体积呈正相关；与丘脑，小脑，脑桥和右侧海马旁灰质体积负相关。结论：前额叶-丘脑-小脑灰质网络的体积改变可能导致精神分裂症患者的执行功能障碍。(c) 2007 Elsevier B.V.版权所有
Objective: Poor executive functioning is a core deficit in schizophrenia and has been linked to frontal lobe alterations. We aimed to identify (1) prefrontal cerebral areas in which decreased volume is linked to executive dysfunction in schizophrenia; and (2) areas throughout the brain that are volumetrically related to the prefrontal area identified in the first analysis, thus detecting more extended volumetric networks associated with executive functioning.Method: Fifty-three outpatients with schizophrenia and 62 healthy controls, matched for age, gender and handedness, were recruited. High-resolution images were acquired on a 1.5 tesla scanner and regional gray and white matter volumes were analyzed by voxel-based morphometry within SPM5 (statistical parametric mapping, University College London, UK). Executive functioning was assessed using the Wisconsin Card Sorting Test (WCST).Results: Twenty-one patients with poor executive functioning showed reduced dorsolateral prefrontal and anterior cingulate gray matter volume as compared to 30 patients with high WCST performance, with a maximum effect in the left dorsolateral prefrontal cortex. Left dorsolateral prefrontal gray matter volume predicted WCST performance after controlling for possible confounding effects of global cognitive functioning, verbal attention span, negative symptoms, illness duration and education. In this area, both patient groups had less gray matter than healthy controls. Left dorsolateral prefrontal gray matter volume was positively related to dorsal prefrontal, anterior cingulate and parietal gray matter volume; and negatively related to thalamic, cerebellar, pontine and right parahippocampal gray matter volume.Conclusions: Volumetric alterations in prefrontal-thalamic-cerebellar gray matter networks may lead to executive dysfunction in schizophrenia. (c) 2007 Elsevier B.V. All rights reserved.