Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure
Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure
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DOI：
10.1073/pnas.0408725102
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发表时间：
2005-04-05
影响因子：
11.1
通讯作者：
Riley, EM
中科院分区：
文献类型：
--
作者：
Drakeley, CJ;Corran, PH;Riley, EM
快速评估疟疾传播强度的新工具将大大促进疟疾控制方案的实施和评估。由于抗疟抗体的获得和维持取决于疟疾感染的暴露，因此这些抗体可用作传播强度的替代措施。我们比较了IgG抗体的流行率与三个疟原虫，恶性疟原虫无性阶段抗原的个人生活在不同的海拔高度，包括一系列的传播强度从高到低流行在坦桑尼亚东北部，与其他措施的传播强度。裂殖子表面蛋白-1抗体的流行率与海拔高度的相关性显著高于疟疾寄生虫血症的点流行率或血红蛋白浓度的单一指标。对特定年龄血清阳性率的分析使人们能够区分传播强度的近期（季节性）变化和长期传播趋势，并利用血清转换年率的数学模型，估计抗体反应的寿命。因此，血清学工具使我们能够检测疟疾传播随时间的变化。这些工具对于监测疟疾流行趋势和疟疾控制方案的有效性将是非常宝贵的。
The implementation and evaluation of malaria control programs would be greatly facilitated by new tools for the rapid assessment of malaria transmission intensity. Because acquisition and maintenance of antimalarial antibodies depend on exposure to malaria infection, such antibodies might be used as proxy measures of transmission intensity. We have compared the prevalence of IgG antibodies with three Plasmodium, falciparum asexual stage antigens in individuals of all ages living at varying altitudes encompassing a range of transmission intensities from hyper- to hypoendemic in northeastern Tanzania, with alternative measures of transmission intensity. The prevalence of antibodies to merozoite surface protein-1(19) was significantly more closely correlated with altitude than either point-prevalence malaria parasitemia or single measures of hemoglobin concentration. Analysis of age-specific seroprevalence rates enabled differentiation of recent (seasonal) changes in transmission intensity from longer-term transmission trends and, using a mathematical model of the annual rate of seroconversion, estimation of the longevity of the antibody response. Thus, serological tools allow us to detect variations in malaria transmission over time. Such tools will be invaluable for monitoring trends in malaria endemicity and the effectiveness of malaria control programs.