Crohn's disease. Clinical manifestations.
Crohn's disease. Clinical manifestations.
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克罗恩病。
DOI：
10.3109/00365528509089192
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发表时间：
1985
影响因子：
1.9
通讯作者：
E. Gjone
中科院分区：
文献类型：
--
作者：
E. Lind;O. Fausa;K. Elgjo;E. Gjone
214例克罗恩病（CD）连续入院，在5年的时间内，观察了平均9年（范围，0-35年）。65%的人在10至30岁之间出现初始症状，9.2%的人在50岁之后出现症状。CD诊断延迟超过10年的8%（平均4.5年;范围0-31年）。大肠受累见于82.5%，是四分之一患者的唯一局限性疾病。三分之二的回肠或回结肠疾病患者发生复发性腹痛。急性腹痛是14%回结肠CD患者剖腹手术的原因。腹泻和直肠出血在结肠CD中更常见，而瘘管并发回结肠疾病比孤立的小肠或大肠受累更常见。在117例患者（55%）中观察到相关的肠外疾病，最常见的与结肠受累相关（关节疾病，21%;眼睛，12%，皮肤，8%）。在26名肝脏病理患者（12%）中，10名患者有淀粉样蛋白沉积。淀粉样变性共12例（6%）。
Two hundred and fourteen patients with Crohn's disease (CD) consecutively admitted during a 5-year period were observed for a mean of 9 years (range, 0-35 years). Sixty-five per cent had their initial symptoms between 10 and 30 years of age and 9.2% after the age of 50 years. The CD diagnosis was delayed for more than 10 years in 8% (mean, 4.5; range, 0-31 years). Large-bowel involvement was seen in 82.5% and was the only localization of the disease in a fourth of the patients. Recurrent abdominal pain occurred in two-thirds of patients with ileal or ileocolic disease. Acute abdominal pain was the cause of laparotomy in 14% of the patients with ileocolic CD. Diarrhea and rectal bleeding occurred significantly more often in colonic CD, whereas fistula complicated ileocolic disease more often than isolated involvement of small or large bowel. Associated extraintestinal diseases were seen in 117 patients (55%), most frequently related to colonic involvement (joint disease, 21%; eye, 12%, skin, 8%). Of 26 patients (12%) with liver pathology, 10 patients had amyloid deposits. Amyloidosis was diagnosed in altogether 12 patients (6%).