Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study.
Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study.
复制标题
急性缺血性中风半暗带的分子特征：一项试点转录组学研究。
DOI：
10.1002/acn3.757
复制
发表时间：
2019
影响因子：
5.3
通讯作者：
Latour,LawrenceL
中科院分区：
文献类型：
--
作者：
Nadareishvili,Zurab;Kelley,Devon;Luby,Marie;Simpkins,AlexisN;Leigh,Richard;Lynch,JohnK;Hsia,AmieW;Benson,RichardT;Johnson,KoryR;Hallenbeck,JohnM;Latour,LawrenceL
我们的目的是描述急性缺血性脑卒中患者外周血中定义为MRI灌注-扩散不匹配（PD MM）的半暗带的外周血基因表达谱。我们研究了23名患者。观察到灌注-扩散错配体积与34个基因的表达相关且显著相关，包括与炎症、SUMO化和凝血相关的基因;而脂多糖抑制被确定为这些过程的候选上游调节因子（z‐score − 2.38，P = 0.04）。半影体积与外周血中的特定基因表达谱相关，其特征在于由脂多糖抑制调节的炎症和神经保护途径的重叠。
We aimed to characterize peripheral blood gene expression profile of penumbra defined as MRI perfusion–diffusion mismatch (PD MM) in peripheral blood of patients with acute ischemic stroke. We studied 23 patients. Perfusion–diffusion mismatch volume was observed to be associated and significantly correlated with the expression of 34 genes including those related to inflammation, SUMOylation, and coagulation; while lipopolysaccharide inhibition was identified to be a candidate upstream regulator of these processes (z‐score −2.38,P= 0.04). Penumbral volume is correlated with a specific gene expression profile in the peripheral blood characterized by overlap of inflammatory and neuroprotective pathways that are regulated by lipopolysaccharide inhibition.